Results 161 to 170 of about 8,444 (178)

Artificial microRNA suppresses C9ORF72 variants and decreases toxic dipeptide repeat proteins in vivo

Gene Therapy, 2023
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor neurons, causing progressive muscle weakness and respiratory failure. The presence of an expanded hexanucleotide repeat in chromosome 9 open reading frame 72 (C9ORF72) is the most frequent mutation causing familial ALS and frontotemporal dementia (FTD).
Gabriela Toro Cabrera, Katharina E. Meijboom, Abbas Abdallah, Helene Tran, Zachariah Foster, Alexandra Weiss, Nicholas Wightman, Rachel Stock, Tania Gendron, Alisha Gruntman, Anthony Giampetruzzi, Leonard Petrucelli, Robert H. Brown, Christian Mueller   +13 more
openaire   +2 more sources

Cloning and characterization of cDNAs for novel proteins with glutamic acid-proline dipeptide tandem repeats

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1996
cDNAs with identical 3' sequences containing a hexanucleotide repeat -(GAGCCG)9- were isolated from rat pheochromocytoma and brain cDNA libraries. The cDNA with the longest open reading frame codes for a protein of 24.6 kDa containing a 16-fold -(Glu-Pro)- dipeptide repeat within a glutamate and proline rich region at its deduced C-terminus. cDNAs with
R, Geertman, A, McMahon, E L, Sabban
openaire   +2 more sources

Plasmodium falciparum: D260, an Intraerythrocytic Parasite Protein, Is a Member of the Glutamic Acid Dipeptide-Repeat Family of Proteins

Experimental Parasitology, 1995
Members of a serologically cross-reacting family of proteins including Ag332 and Pf11.1, megadalton proteins of schizont-infected red blood cells, and gametocytes, respectively, and Pf155-RESA, a 155-kDa protein of ring-infected red blood cells, have been reported to share amino acid repeat sequences.
D A, Barnes, W, Wollish, R G, Nelson, J H, Leech, C, Petersen   +4 more
openaire   +2 more sources

Dipeptide Repeat Pathology in C9orf72-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance

Antioxidants, 2022
JOSÉ Jimenez-Villegas, Janine Kirby, Ana Mata   +2 more
exaly  

[P1–024]: C9ORF72 DIPEPTIDE REPEAT PROTEINS DISRUPT NUCLEOCYTOPLASMIC TRANSPORT

Alzheimer's & Dementia, 2017
Sarah Ryan, Sara Rollinson, Janis Bennion Callister, Eleanor Hobbs, Stuart Pickering‐Brown   +4 more
openaire   +1 more source

Correction to: Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins

Acta Neuropathologica
Mori, K., Arzberger, T., Grässer, F.A., Gijselinck, I., May, S., Rentzsch, K., Weng, S.M., Schludi, M.H., van der Zee, J., Cruts, M., van Broeckhoven, C., Kremmer, E., Kretzschmar, H.A., Haass, C., Edbauer, D.   +14 more
openaire   +3 more sources

[P1–203]: C9ORF72 DIPEPTIDE REPEAT PROTEINS DISRUPT NUCLEOCYTOPLASMIC TRANSPORT

Alzheimer's & Dementia, 2017
Sarah Ryan, Sara Rollinson, Janis Bennion Callister, Eleanor Hobbs, Stuart Pickering‐Brown   +4 more
openaire   +1 more source

Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis

Acta Neuropathologica, 2017
Shahram Saberi, Jie Jiang, Sandra Diaz Garcia   +2 more
exaly  

Dipeptide repeat derived from C9orf72 hexanucleotide expansions forms amyloids or natively unfolded structures in vitro

Biochemical and Biophysical Research Communications, 2020
Jehan Waeytens, Ronald Melki, Luc Bousset   +2 more
exaly  

Prevalence of brain and spinal cord inclusions, including dipeptide repeat proteins, in patients with the C9ORF72 hexanucleotide repeat expansion: a systematic neuropathological review

Neuropathology and Applied Neurobiology, 2016
Joost Raaphorst, Eleonora Aronica, Frank Baas   +2 more
exaly