Results 61 to 70 of about 8,444 (178)

Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis. [PDF]

Acta Neuropathol, 2018
Hexanucleotide repeat expansions in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (C9 ALS). The main hypothesized pathogenic mechanisms are C9orf72 haploinsufficiency and/or toxicity from one or more of bi-directionally ...
Saberi S, Stauffer JE, Jiang J, Garcia SD, Taylor AE, Schulte D, Ohkubo T, Schloffman CL, Maldonado M, Baughn M, Rodriguez MJ, Pizzo D, Cleveland D, Ravits J.   +13 more
europepmc   +2 more sources

Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome

Cell Reports, 2023
Summary: Expansion of the hexanucleotide repeat GGGGCC in the C9orf72 gene is the most common genetic factor in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Xiaoqiu Shu, Chen Wei, Wen-Yo Tu, Keke Zhong, Shuyuan Qi, Ailian Wang, Lei Bai, Shan-Xin Zhang, Benyan Luo, Zhen-Zhong Xu, Kejing Zhang, Chengyong Shen   +11 more
doaj   +1 more source

Dipeptide Repeat Pathology in C9orf72-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance

Antioxidants, 2022
The hexanucleotide expansion of the C9orf72 gene is found in 40% of familial amyotrophic lateral sclerosis (ALS) patients. This genetic alteration has been connected with impaired management of reactive oxygen species.
José Jiménez-Villegas, Janine Kirby, Ana Mata, Susana Cadenas, Martin R. Turner, Andrea Malaspina, Pamela J. Shaw, Antonio Cuadrado, Ana I. Rojo   +8 more
doaj   +1 more source

C9orf72 arginine‐rich dipeptide repeat proteins promote assembly and impair dynamics of processing body [PDF]

Alzheimers Dement
Background G4C2 repeat expansions in C9orf72 gene are the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).
Zhang Y, Wu Y, Shao W, Gendron T, Noya J, Jones C, Jansen‐West K, Daughrity L, Castanedes‐Casey M, Oskarsson B, Dickson D, Petrucelli L.   +11 more
europepmc   +2 more sources

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

AI‐Physics‐Experiment Trinity for Integrated Protein Dynamics Modeling

Advanced Science, EarlyView.
This review unites experiments, physics‐based simulations, and AI as a synergistic triad for protein dynamics modeling. It highlights integrative strategies, resolves sampling and forcefield bottlenecks, and outlines challenges and future directions for accurate, interpretable conformational ensemble prediction.
Chen Shi, Minying Low, Peng Xiu, Kresten Lindorff‐Larsen, Yong Wang   +4 more
wiley   +1 more source

C9orf72 Hexanucleotide Repeat Expansion-Related Neuropathology Is Attenuated by Nasal Rifampicin in Mice

Biomedicines, 2022
The non-coding GGGGCC hexanucleotide repeat expansion (HRE) in C9orf72 gene is a dominant cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).
Yukari Hatanaka, Tomohiro Umeda, Keiko Shigemori, Toshihide Takeuchi, Yoshitaka Nagai, Takami Tomiyama   +5 more
doaj   +1 more source

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, EarlyView.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source

Binding of the heterogeneous ribonucleoprotein K (hnRNP K) to the Epstein-Barr virus nuclear antigen 2 (EBNA2) enhances viral LMP2A expression. [PDF]

, 2012
The Epstein-Barr Virus (EBV) -encoded EBNA2 protein, which is essential for the in vitro transformation of B-lymphocytes, interferes with cellular processes by binding to proteins via conserved sequence motifs.
Stephanie Barth, Neuenkirchen, N., Alfredo Mamiani (146650), Grässer, Friedrich A., Ostareck-Lederer, Antje, Leonhardt, Heinrich, Nils Neuenkirchen (146673), Fischer, Utz, Bodo Moritz, Friedrich A Grässer, Wen Deng, Masouris, Ilias, Barth, Stephanie, Fischer, U., Hennard, C., Christian Cassel, Neuenkirchen, Nils, Utz Fischer (146680), Utz Fischer, Ute Stober-Grässer (146645), Elfriede Noessner (146689), Noessner, Elfriede, Henrik Gross (146622), Bodo Moritz (146655), Dirk Ostareck, Mamiani, Alfredo, Stephanie Barth (145387), Nößner, E., Alfredo Mamiani, Ostareck, Dirk, Christine Hennard (146627), Christian Cassel (146638), Moritz, Bodo, Antje Ostareck-Lederer, Elfriede Noessner, Deng, Wen, Gross, H., Christine Hennard, Ostareck, Dirk H., Antje Ostareck-Lederer (146668), Dirk Ostareck (146662), Heinrich Leonhardt (18589), Henrik Gross, Stober-Grässer, U., Masouris, I., Friedrich A. Grässer (145412), Kremmer, E., Wen Deng (123626), Grässer, F.A., Kremmer, Elisabeth, Cassel, C., Deng, W., Ilias Masouris (146632), Ilias Masouris, Ostareck-Lederer, A., Mamiani, A., Heinrich Leonhardt, Gross, Henrik, Moritz, B., Nils Neuenkirchen, Barth, S., Ostareck, D., Cassel, Christian, Stober-Grässer, Ute, Elisabeth Kremmer (17351), Ute Stober-Grässer, Elisabeth Kremmer, Leonhardt, H., Hennard, Christine   +68 more
core   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source