Results 91 to 100 of about 22,784 (283)

A Facile Method for Screening DPP IV Inhibitors in Living Cell System Based on Enzyme Activity Probe

Journal of Analytical Methods in Chemistry
Dipeptidyl peptidase IV (DPP IV), one of the most essential peptidase, is widely distributed in various organs and tissues of the human body, which affects protein stability by acting on peptide bonds at the end of peptide chains and is further involved ...
Shu-Mei Pan, Chun-Yu Xing, Hong-Wei Li, Rui-Min Wang, Xin-Yue Pu, Tie-Gang Wang, Dan-Dan Wang, Li-Wei Zou   +7 more
doaj   +1 more source

Degradation and Stabilization of Peptide Hormones in Human Blood Specimens. [PDF]

PLoS ONE, 2015
Plasma hormone peptides, including GLP-1, GIP, Glucagon, and OXM, possess multiple physiological roles and potential therapeutic and diagnostic utility as biomarkers in the research of metabolic disorders.
Jizu Yi, David Warunek, David Craft
doaj   +1 more source

Antidiabetic Potential of Ligands from NEIST_PMIB_06, Bacterium Associated with Hawaijar (Fermented Soy Food): Insight from in Vitro and in Silico Studies

ChemFoodChem, EarlyView.
ABSTRACT In this study, a bacterium (NEIST_PMIB_06) was isolated from Hawaijar, a fermented soy food from Manipur, Northeast India. The bacterium was inoculated and incubated to isolate bioactive compounds. Liquid‐liquid extraction was performed to obtain extracts (cell‐free and cell‐based), and their efficacy was evaluated.
A Ibeyaima, Hiranmoy Barman, Prasenjit Manna   +2 more
wiley   +1 more source

Efecto inhibitorio de un extracto acuoso de las hojas de Allophylus cominia (L.) Sw sobre las proteínas tirosina fosfatasa 1B y dipeptidil peptidasa IV [PDF]

, 2014
Introduction: Allophylus cominia (L.) Sw is a Cuban medicinal plant used by traditional medicine for the treatment of diabetes with unknown mechanisms of action.
L. Harvey, Alan, Marrero Faz, Evangelina, Sánchez Calero, Janet, Young, Louise C.   +3 more
core  

Dipeptidyl-peptidase IV inhibitor (DPP4i) confers increased odds of bullous pemphigoid even years after drug initiation [PDF]

, 2022
Khalaf Kridin, Orly Avni, Giovanni Damiani, Dana Tzur Bitan, Erez Onn, Orly Weinstein, Arnon D. Cohen   +6 more
openalex   +1 more source

Emulating Six Cardiovascular Outcome Trials of Antidiabetic Drugs in Individuals with Type 2 Diabetes: Analyses Based on Real‐World Databases from Korea and Taiwan

Clinical Pharmacology &Therapeutics, EarlyView.
With the increasing volume of clinical evidence derived from large‐scale Asian real‐world data (RWD) and the growing interest in its use in regulatory decision‐making, it is important to conduct benchmarking exercises that evaluate whether studies using Asian RWD can generate similar conclusions as randomized controlled trials (RCTs).
Hwa Yeon Ko, Philip C. M. Au, Michael Chun‐Yuan Cheng, Ching‐Lung Cheung, Ahhyung Choi, Miyuki Hsing‐Chun Hsieh, Han Eol Jeong, Edward Chia‐Cheng Lai, Brian Meng‐Hsun Li, Kenneth K. C. Man, Jeremy A. Rassen, Daniel Hsiang‐Te Tsai, Shirley V. Wang, Ian C. K. Wong, Ju‐Young Shin, Sohee Park   +15 more
wiley   +1 more source

DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid [PDF]

, 2016
Additional file 3: Figure S2. Liver and epididymal fat weights in db/+ mice and db/db mice. The experiments were performed in db/+ or db/db mice fed an SL diet, SO diet, SL containing DPP-4 inhibitor (0.4% des-fluoro-sitagliptin) diet, or SO containing ...
Eiko Yoshida, Hajime Sasaki, Jun Shirakawa, Kazuki Tajima, Mayu Kyohara, Megumi Koganei, Mitsuyo Kaji, Shunsuke Yamazaki, Tomoko Okuyama, Yasuo Terauchi, Yu Togashi   +10 more
core   +5 more sources

Current Advancements of Probiotic Foods and Their Role in Sustainable Food Security

Food Bioengineering, EarlyView.
ABSTRACT Probiotic foods have evolved from traditional fermented products to scientifically validated functional foods, defined by the FAO and WHO as live microorganism that confer a health benefit on the host when administered in adequate amounts, with effects being strain, does and end point specific.
Ashenafi Teklay Yaekob, Gebremedhin Gebreslassie, Etsay Mesele, Tesfakiros Semere   +3 more
wiley   +1 more source

Dual‐Functional Food‐Derived Bioactive Peptides: Expanding Beyond Biological Activity

Food Chemistry International, EarlyView.
This review examines recent advances in dual‐ and multifunctional food‐derived bioactive peptides, highlights emerging research integrating biological and techno‐functional properties, and offers perspectives to inform future studies in this field. ABSTRACT Food‐derived bioactive peptides (FBPs) are a diverse group of peptides with proven physiological
Cullen MacDonald, Xiaohong Sun
wiley   +1 more source

A Dipeptidyl Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Improves Endothelial Function and Reduces Atherosclerotic Lesion Formation in Apolipoprotein E–Deficient Mice [PDF]

, 2005
ObjectivesThe aim of this study was to investigate the antiatherogenic effects of the dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin (DFS).BackgroundThe new class of anti–type 2 diabetes drugs, dipeptidyl peptidase-4 inhibitors, improves ...
Matsubara, Junichi, Sugiyama, Seigo, Sugamura, Koichi, Nakamura, Taishi, Fujiwara, Yukio, Akiyama, Eiichi, Kurokawa, Hirofumi, Nozaki, Toshimitsu, Ohba, Keisuke, Konishi, Masaaki, Maeda, Hirofumi, Izumiya, Yasuhiro, Kaikita, Koichi, Sumida, Hitoshi, Jinnouchi, Hideaki, Matsui, Kunihiko, Kim-Mitsuyama, Shokei, Takeya, Motohiro, Ogawa, Hisao   +18 more
core   +1 more source