Results 91 to 100 of about 134,595 (257)
Advanced Science, Volume 13, Issue 3, 14 January 2026.This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan +12 more
wiley +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan +9 more
wiley +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.Puerarin targets mitochondrial MIC19 in tumor‐infiltrating Tregs, impairing their immunosuppressive function and enhancing antitumor immunity. This study uncovers the metabolic dependency of tumor‐infiltrating Tregs and highlights a potential metabolic‐targeted immunotherapeutic strategy for liver cancer. Abstract Regulatory T cells (Tregs) are pivotal
Yu Li +10 more
wiley +1 more source
Chemical Engineering &Technology, Volume 49, Issue 1, January 2026.This review presents the state‐of‐the‐art knowledge on vibromixers, which are alternative mixing systems to conventional rotating agitators and mostly used in the biotechnology sector. It critically surveys the working principles of different vibromixer types and their operating conditions, the designs and key geometrical parameters, hydrodynamics and ...
Muhammad Muhammad Gimba +2 more
wiley +1 more source
Cancer, Volume 132, Issue 1, 1 January 2026.Abstract Background Blastic plasmacytoid dendritic cell neoplasm (BPDCN), an aggressive hematologic neoplasm that expresses CD123, is often observed in the bone marrow (BM), as well as skin, blood, and viscera. Tagraxofusp, a first‐in‐class CD123‐targeted therapy, is the only drug approved to treat BPDCN.
Marina Konopleva +10 more
wiley +1 more source
Clinical spectrum and outcomes of pediatric diphtheria
, 2019 Herry D. Nawing +3 more
openalex +2 more sources
Efzimfotase Alfa Improves Respiratory Capacity in Muscle Tissue From a Mouse Model of HPP
JIMD Reports, Volume 67, Issue 1, January 2026.ABSTRACT Hypophosphatasia (HPP) is an inherited metabolic disease caused by deficient tissue‐nonspecific alkaline phosphatase (ALP) activity and characterized by skeletal and nonskeletal symptoms, including muscle weakness and fatigue. We hypothesized that mitochondrial respiration is impaired in muscle in HPP, independent of skeletal manifestations ...
Denise Devore +10 more
wiley +1 more source