Results 61 to 70 of about 242,143 (321)

Studies on the denaturation of antibody. IV. The influence of pH and certain other factors on the rate of inactivation of Staphylococcus antitoxin in urea solutions [PDF]

, 1948
In previous work on the denaturation of antibody, studies have been made of some of the factors influencing the inactivation of diphtheria antitoxin in urea solutions (1, 2).
Schomaker, Verner, Wright, George G.
core  

Pregnancy has a minimal impact on the acute transcriptional signature to vaccination. [PDF]

, 2020
Vaccination in pregnancy is an effective tool to protect both the mother and infant; vaccines against influenza, pertussis and tetanus are currently recommended.
Aerssens, A, Calvert, A, Cizmeci, D, Hake, D, Jones, CE, Kaufmann, SHE, Leroux-Roels, G, Maertzdorf, J, Maes, C, Tregoning, JS, Weiner, J   +10 more
core   +1 more source

Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti–PD-1 in melanoma

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Regulatory T cells (Tregs) infiltrate tumors in various cancers and promote an immunosuppressive microenvironment that hinders antitumor immunity. Denileukin diftitox, a diphtheria-toxin–based fusion protein that depletes Tregs, was approved
Laurene S Cheung, Juan Fu, Pankaj Kumar, Amit Kumar, Michael E. Urbanowski, Elizabeth A. Ihms, S. Parveen, C. K. Bullen, G. Patrick, R. Harrison, J. Murphy, D. Pardoll, W. Bishai   +12 more
semanticscholar   +1 more source

Regulating PPARG Reduces Lipid Accumulation in Microglia and Promotes Functional Recovery After Spinal Cord Injury

Advanced Science, EarlyView.
Macrophages infiltrate the spinal cord post‐injury, decreasing over time. Microglia phagocytose myelin debris, increasing lipid accumulation. Macrophage deletion improves outcomes, while microglial deletion worsens them. The LD+ microglia subtype shows abnormal Pparg signaling.
Mingran Luo, Jiayun Liu, Yunxin Su, Tao Jiang, Xincan Wu, Peng Gao, Tao Qin, Mengyuan Wu, Qingqing Li, Shujun Zhang, Baorong He, Yongxiang Wang, Xiaodong Guo, Wei Zhou, Shujie Zhao, Jin Fan, Jian Chen, Guoyong Yin   +17 more
wiley   +1 more source

Diphtheria and pseudo‐diphtheria bacilli [PDF]

The Journal of Pathology and Bacteriology, 1897
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openaire   +2 more sources

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

A diphtheria outbreak in Johor Bahru, Malaysia: Public health investigation and response

Journal of Infection in Developing Countries, 2022
Introduction: Diphtheria is an acute infectious disease caused by Corynebacterium diphtheriae. Although the incidence of diphtheria worldwide has rapidly declined following the largely successful diphtheria toxoid-based vaccines, concerns persist for ...
Peter Seah Keng Tok, Misbaha Jilani, Nurul Fateha Misnar, Nor Suzila Bidin, Norli Rosli, Haidar Rizal Toha   +5 more
doaj   +1 more source

Rare human skin infection with Corynebacterium ulcerans: transmission by a domestic cat [PDF]

, 2018
Corynebacterium ulcerans is mainly known for its ability to cause animal infections. Some strains of C. ulcerans produce diphtheria toxin, which can cause life-threatening cardiopathies and neuropathies in humans. Human cutaneous C. ulcerans infection is
Bloemberg, G., Borelli, S., Corti, M., Eich, G., Hoelzle, L., Kutzner, H., Lautenschlager, S.   +6 more
core  

Risk Factors For Multiple Sclerosis In Volyn Region (Ukraine) [PDF]

, 2016
The prevalence rate of multiple sclerosis (MS) in Volyn Region (101.0 per 100000) is the highest in Ukraine. To study MS risk factors in Volyn Region, special questionnaires were distributed among all MS patients residing in Volyn region.
Bobryk, N. (Nataliia), Sokolova, L. (Larysa)   +1 more
core   +2 more sources

Diphtheria toxin time-resolved absorption and resonance ft-ir and raman biospectroscopy and density functional theory (dft) investigation of vibronic-mode coupling structure in vibrational spectra analysis: a spectroscopic study on an anti-cancer drug

Clinical Case Studies and Reports, 2019
Diphtheria toxin is an exotoxin secreted by Corynebacterium diphtheriae, the pathogenic bacterium that causes diphtheria. Unusually, the toxin gene is encoded by a bacteriophage (a virus that infects bacteria).
A. Heidari, J. Esposito, Angela Caissutti   +2 more
semanticscholar   +1 more source