Results 61 to 70 of about 142,634 (201)

The vaccine coverage and vaccine immunity status and risk factors of non-protective levels of antibodies against vaccines in children with juvenile idiopathic arthritis: cross-sectional Russian tertiary Centre study

Pediatric Rheumatology Online Journal, 2021
Background Immunosuppressive drugs, incomplete vaccine coverage, immune system dysregulation might be factors of a low level of anti-vaccine antibodies in JIA patients. The study aimed to evaluate vaccine coverage, post-vaccine immunity, and risk factors
Mikhail M. Kostik, Natalia A. Lubimova, Irina V. Fridman, Olga V. Goleva, Susanna M. Kharit   +4 more
doaj   +1 more source

The European Diphtheria Surveillance Network (ESDN) a strong model to combat a rare disease and use resources efficiently, share knowledge openly, and give support effectively [PDF]

, 2012
Maria Paula Bajanca Lavado é a microbiologista responsável pela Diphtheria em Portugal e representa Portugal no ECDC no Grupo "The European Diphtheria Surveillance Network (EDSN)".BACKGROUND: As diphtheria is uncommon within the EU, complacency and ...
Efstratiou, Androulla, Neal, Shona, The European Diphtheria Surveillance Network, EDSN   +2 more
core   +1 more source

Haemophilus influenzae type b reemergence after combination immunization [PDF]

, 2006
An increase in Haemophilus influenzae type b (Hib) in British children has been linked to the widespread use of a diphtheria/tetanus/acellular pertussis combination vaccine (DTaP-Hib).
Mary P.E. Slack, Heath, PT, Diane Irving, Slack, MPE, Nik G. Johnson, Lee, YC ; https://orcid.org/, Irving, D, Sheldon, J, Gail F. Balfour, Joanna Sheldon, Johnson, NG, Ruggeberg, JU, Balfour, GF, Slack, MP, Y. Chen Lee, Heath, PI, Pollard, AJ, Jens U. Ruggeberg, Paul T. Heath, Andrew J. Pollard, Lee, YC, Liddy, H, Helen Liddy   +22 more
core   +1 more source

Seroprevalence of diphtheria IgG antibodies among 5–20 years old in diphtheria affected regions during 2018–19: Evidence in support of the revised National Vaccine Policy for diphtheria in India

Clinical Epidemiology and Global Health
Background: Diphtheria continues to be a public health problem in India as it is re-emerging in several regions of the country. In recent times, apart from preschool-aged children, diphtheria outbreaks are seen to affect older children and adults.
Bindu R. Madhavi, Anitha Deva, Mahendra M. Reddy, P.M. Beena, S.N. Vijay Kumar   +4 more
doaj   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Daraxonrasib and Beyond: Pan‐RAS Inhibition, Resistance, and Next‐Generation Strategies

Cancer Science, EarlyView.
ABSTRACT RAS proteins have long been considered difficult therapeutic targets, but allele‐selective inhibitors established the clinical tractability of mutant RAS. Daraxonrasib (RMC‐6236), an oral pan‐RAS inhibitor, has now extended this concept by targeting multiple mutant and wild‐type RAS proteins.
Ryo Honda
wiley   +1 more source

Targeting a Novel AREG+ Dendritic Cell Alleviates Renal Fibrosis Induced by Ischemia–Reperfusion Injury

Cell Proliferation, EarlyView.
Renal IRI induces tubular EMT and fibrosis. CD11c+AREG+ DCs mediate the process via AREG‐EGFR axis, serving as promising therapeutic targets. ABSTRACT Renal ischemia–reperfusion injury (RIRI) is a major cause of acute tubular damage and a key driver of maladaptive repair and fibrosis.
Xin Luo, Longbin Xiong, Zhaohui Zhou, Lihao Zhang, Yulu Peng, Xiangpeng Zou, Yixin Huang, Yisong Lin, Xiaofeng Yang, Zhanji Zhan, Fangjian Zhou, Youhua Liu, Chunping Yu, Baokui Ye, Zhiling Zhang   +14 more
wiley   +1 more source

Triage in the Time of Diphtheria

Western Journal of Emergency Medicine, 2020
Introduction: A diphtheria outbreak occurred in 2017 in Jakarta, Indonesia, during which our hospital was appointed as a referral hospital where patients with upper respiratory tract symptoms were sent for confirmation of the diagnosis and medical ...
Hadiki Habib, Hesty Kurniawaty
doaj   +1 more source

The H19/miR‐760/BST2 regulatory axis sustains breast cancer tumorigenesis and metastasis

The FEBS Journal, EarlyView.
H19 and BST2 promote breast cancer aggressiveness through their reciprocal coregulation by miR‐760. Since both transcripts are targeted by miR‐760, overexpression of one sequesters the microRNA and relieves repression of the other: H19 raises BST2 levels, and BST2 raises H19 levels.
Kekely Klouyovo, Evodie Peperstraete, Léa Mabille, Joséphine Louvieaux, Jim Marmuse, Clément Lecerf, Chann Lagadec, Xuefen Le Bourhis, Éric Adriaenssens   +8 more
wiley   +1 more source

Dimerization of human PARP15 is required for NAD+ binding and automodification

The FEBS Journal, EarlyView.
This study provides an integrated structural model of human PARP15. Biophysical, enzymatic, and cell‐based analyses identify the dimer as the active oligomeric state capable of binding the substrate NAD+. A co‐crystal structure with a non‐hydrolyzable substrate analog BAD reveals the molecular basis for the dimerization requirement.
Anna Tuovinen, Johan Pääkkönen, Mirko M. Maksimainen, Lea Hirschen, Heli I. Hentilä, Marie Tauscher, Bernhard Lüscher, Carlos Vela‐Rodríguez, Patricia Korn, Lari Lehtiö   +9 more
wiley   +1 more source