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Crystallization of diphtheria toxin

Journal of Molecular Biology, 1991
Two new crystal forms (forms III and IV) have been grown of diphtheria toxin (DT), which kills susceptible cells by catalyzing the ADP-ribosylation of elongation factor 2, thereby stopping protein synthesis. Forms III and IV diffract to 2.3 A and 2.7 A resolution, respectively.
Seunghyon Choe   +3 more
openaire   +3 more sources

Hydrogen-Deuterium Exchange Epitope Mapping Reveals Distinct Neutralizing Mechanisms for Two Monoclonal Antibodies against Diphtheria Toxin.

Biochemistry, 2019
The diphtheria toxoid (DT) antigen is one of the major components in pediatric and booster combination vaccines and is known to raise a protective humoral immune response upon vaccination.
Shaolong Zhu   +7 more
semanticscholar   +1 more source

On the formation of diphtheria toxin in saliva byC. diphtheriae

Antonie van Leeuwenhoek, 1953
1. The iron contents of a number of saliva samples were determined. The iron contents found varied from 0.10–0.61 γ per g of saliva, while in some cases the iron quantity present was so small that it could not be determined. 2. These iron contents are of the same quantitative order as the concentrations of this element in the various ...
L. Smith, A. Tasman
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Diphtheria Toxin and the Diphtheria-Toxin Receptor

2000
The discovery of diphtheria toxin from culture medium of Corynehacterium diphtheriae was one of the greatest discoveries in medical history. Since this epoch-making change in medicine, diphtheria toxin has been studied, first to prevent disease and later to understand the pathogenic mechanism at the molecular level. A number of important discoveries in
K. D. Sharma, T. Umata, Eisuke Mekada
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Anaphylaxis to Diphtheria Toxin

The Journal of Immunology, 1932
Abstract Previously reported experiments (1, 2, 3) on anaphylaxis apparently due to the toxin or toxoid antigen were made upon actively sensitized (antitoxic immune) animals. The results had indicated that while other diphtheria antigens participated to some extent, the major part of the anaphylaxis could be assigned to the toxin or ...
John Y Sugg   +2 more
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Diphtheria toxin

2015
Diphtheria toxin (DT) is one of the most extensively studied bacterial toxins with intracellular action. It is produced by toxigenic strains of Corynebacterium diphtheriae and is responsible for the symptoms of diphtheria. The toxin was isolated in 1888. A vaccine was developed in 1923.
Daniel Gillet, Julien Barbier
openaire   +2 more sources

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