Results 41 to 50 of about 23,757 (183)

Effect of Antiplatelet Therapy (Aspirin + Dipyridamole Versus Clopidogrel) on Mortality Outcome in Ischemic Stroke [PDF]

, 2018
The optimal regimen of antiplatelet therapy for secondary prevention in noncardioembolic ischemic stroke remains controversial. We aimed to determine which regimen was associated with the greatest reduction in adverse outcomes.
Barlas, Raphae S., Bettencourt-Silva, Joao H., Bowles, Kristian M., Clark, Allan B., Ford, Isobel, Loke, Yoon K., Mamas, Mamas A, Metcalf, Anthony K., Myint, Phyo K., Potter, John F.   +9 more
core   +2 more sources

Long‐Term Outcomes of Extrahepatic Portal Vein Obstruction—A Nationwide Registry‐Based Follow‐Up Study From 1987 to 2023

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Background and Aims Extrahepatic portal vein obstruction (EHPVO) is among the main causes of childhood portal hypertension. We analysed nationwide long‐term outcomes of EHPVO in relation to various management options. Methods In total, 62 consecutive patients with EHPVO diagnosed between 1987 and 2023 were followed up through hospital records ...
Topi Luoto, Maria Hukkinen, Mikko P. Pakarinen   +2 more
wiley   +1 more source

Multimodal interventions to enhance adherence to secondary preventive medication after stroke: a systematic review and meta-analyses [PDF]

, 2016
Summary: Introduction: Nonadherence to secondary preventative medications after stroke is common and is associated with poor outcomes. Numerous strategies exist to promote adherence.
Al AlShaikh, Sukainah, Dawson, Jesse, Dunn, William, Quinn, Terry, Walters, Matthew   +4 more
core   +1 more source

Distinct Thromboxane A₂–Dependent Pathways Regulate Arachidonic Acid–Triggered VASP Phosphorylation at Ser239 and Ser157 in Human Platelets: Real‐Time Visualization Reveals Superior Antithrombotic Efficacy by Targeting Thromboxane A₂ Signaling over Cyclooxygenase Inhibition

Journal of Cellular Physiology, Volume 241, Issue 3, March 2026.
ABSTRACT Platelets, as anucleate blood cells, play a pivotal role in the pathogenesis of cardiovascular diseases (CVDs), making antiplatelet therapy essential for preventing thrombotic events such as myocardial infarction. Thromboxane A₂ (TXA₂) is a key pro‐aggregatory mediator that drives platelet activation.
Joen‐Rong Sheu, Wei‐Chieh Huang, Chao‐Chien Chang, Chih‐Wei Hsia, Chih‐Hsuan Hsia, Thanasekaran Jayakumar, Shaw‐Min Hou   +6 more
wiley   +1 more source

Reproductive disorders and obstetric complications in gynecological diseases [PDF]

Гинекология, 2018
This publication examines the existing risks of obstetric complications and other reproductive disorders in women with gynecological diseases. The paper also discusses the issues of the pre-school training of women with gynecological diseases, with ...
A L Unanian, I S Sidorova, A D Nikonets, L N Aminova, V A Alimov, A V Shchukina, Yu V Chushkov, D V Baburin   +7 more
doaj   +3 more sources

Kawasaki disease in siblings and a review of drug treatment

Drugs in Context, 2020
We have managed two anonymized siblings with Kawasaki disease (KD). The occurrence of KD in the elder brother alerted us to the occurrence of incomplete KD in the younger brother. Both siblings were treated with intravenous immunoglobulin and a high dose
Steven King-fan Loo, Kam Lun Hon, Alexander KC Leung, Tak Cheung Yung, Man Ching Yam   +4 more
doaj   +1 more source

Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388) [PDF]

, 2015
RATIONALE: The risk of recurrence following a stroke or transient ischemic attack is high, especially immediately after the event. HYPOTHESIS: Because two antiplatelet agents are superior to one in patients with non-cardioembolic events, more ...
Bath, Philip M.W., Beridze, M., Christensen, H., Dineen, Robert A., Duley, Lelia, Heptinstall, Stan, James, M., Markus, H.S., Nikola, N., Pocock, S, Ranta, A., Robinson, T., TARDIS Trial, Venables, G.   +13 more
core   +1 more source

The Role of Extracellular Vesicles in Transient Ischaemic Attacks and Ischaemic Stroke: A Systematic Review

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
Both transient ischaemic attack (TIA) and ischaemic stroke lead to an increase in individual cellular‐derived populations of extracellular vesicles (EVs), including endothelial, platelet and leukocyte derived. These EVs have downstream roles in the pathophysiological events associated with TIA and stroke, including dysregulated inflammation and ...
Rebecca Marie Raven, Philip Eurig James, Keith Morris, Jessica Olivia Williams   +3 more
wiley   +1 more source

Reverse redistribution on Rb-82: Does the mechanism of stress play a role?

World Journal of Nuclear Medicine, 2019
We present a case of reverse redistribution in a patient imaged with Rb-82 positron-emitting tomography. The patient was imaged twice in rapid succession using pharmacological stress – once with dipyridamole and once with dobutamine.
Patrick Martineau, Francois Harel, Matthieu Pelletier-Galarneau   +2 more
doaj   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source