Results 61 to 70 of about 23,468 (210)

Single‐Cell Transcriptome‐Wide Mendelian Randomization and Colocalization Uncover Potential Immunocytes‐Related Therapeutic Targets for Obesity

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Weight‐loss treatment is crucial for individuals with obesity to prevent various complications. The role of Immune cells in obesity has been recently recognized, whereas its translation into therapy requires identifying key target genes. We performed Mendelian randomization (MR) analysis to assess causal relationships between expression ...
Xingjian Zhang, Yong Tian, Xiaoying Ren, Juan Tian, Jia Liu, Guang Wang   +5 more
wiley   +1 more source

ST‐Segment Elevation Following Adenosine Administration for SVT: Diagnostic Challenge in Acute Cardiac Care

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ST segment elevation following adenosine administration in the inferior leads (II, III, aVF). ABSTRACT Adenosine, used to treat paroxysmal supraventricular tachycardia, commonly causes flushing, sweating, palpitations, and hypotension. Rarely, it may induce ST‐segment elevation with chest pain, suggesting transient myocardial ischemia or coronary ...
Sweta Singh, Deepak Jha, Abhishek Thakur, Saurav Jha, Dipesh Kumar Mandal   +4 more
wiley   +1 more source

Extracellular Vesicles as Orchestrators of Osteoimmunomodulation in Peri‐Implantitis: Implications for Bone Regeneration

Clinical Implant Dentistry and Related Research, Volume 28, Issue 2, April 2026.
ABSTRACT Introduction Peri‐implantitis, characterized by inflammatory bone loss, is a leading cause of dental implant failure. Current regenerative strategies face limitations due to the persistent inflammatory microenvironment. Mesenchymal stem cell‐derived extracellular vesicles (MSC‐EVs) have emerged as promising acellular therapeutics with dual ...
Marco Bonilla, María Carretero‐Fernández, Juan Sainz, Francisco Mesa   +3 more
wiley   +1 more source

Dipyridamole

Reactions Weekly
Ali Hassan R, Patel P.
europepmc   +2 more sources

Long‐Term Outcomes of Extrahepatic Portal Vein Obstruction—A Nationwide Registry‐Based Follow‐Up Study From 1987 to 2023

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Background and Aims Extrahepatic portal vein obstruction (EHPVO) is among the main causes of childhood portal hypertension. We analysed nationwide long‐term outcomes of EHPVO in relation to various management options. Methods In total, 62 consecutive patients with EHPVO diagnosed between 1987 and 2023 were followed up through hospital records ...
Topi Luoto, Maria Hukkinen, Mikko P. Pakarinen   +2 more
wiley   +1 more source

Distinct Thromboxane A₂–Dependent Pathways Regulate Arachidonic Acid–Triggered VASP Phosphorylation at Ser239 and Ser157 in Human Platelets: Real‐Time Visualization Reveals Superior Antithrombotic Efficacy by Targeting Thromboxane A₂ Signaling over Cyclooxygenase Inhibition

Journal of Cellular Physiology, Volume 241, Issue 3, March 2026.
ABSTRACT Platelets, as anucleate blood cells, play a pivotal role in the pathogenesis of cardiovascular diseases (CVDs), making antiplatelet therapy essential for preventing thrombotic events such as myocardial infarction. Thromboxane A₂ (TXA₂) is a key pro‐aggregatory mediator that drives platelet activation.
Joen‐Rong Sheu, Wei‐Chieh Huang, Chao‐Chien Chang, Chih‐Wei Hsia, Chih‐Hsuan Hsia, Thanasekaran Jayakumar, Shaw‐Min Hou   +6 more
wiley   +1 more source

Dipyridamole reduces penile apoptosis in a rat model of post-prostatectomy erectile dysfunction

International Brazilian Journal of Urology
Purpose: Despite the nerve-sparing technique, many patients suffer from erectile dysfunction after radical prostatectomy (RP) due to cavernous nerve injury. The aim of this study was to evaluate dipyridamole as a potential treatment agent of post-radical
Omer Kutlu, Ersagun Karaguzel, Ali Ertan Okatan, Ahmet Mentese, Esin Yulug, Ilke Onur Kazaz, Selcuk Kutlu, Eyup Dil, Huseyin Eren, Ahmet Alver   +9 more
doaj   +1 more source

The Role of Extracellular Vesicles in Transient Ischaemic Attacks and Ischaemic Stroke: A Systematic Review

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
Both transient ischaemic attack (TIA) and ischaemic stroke lead to an increase in individual cellular‐derived populations of extracellular vesicles (EVs), including endothelial, platelet and leukocyte derived. These EVs have downstream roles in the pathophysiological events associated with TIA and stroke, including dysregulated inflammation and ...
Rebecca Marie Raven, Philip Eurig James, Keith Morris, Jessica Olivia Williams   +3 more
wiley   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Repurposing of the Cardiovascular Drug Statin for the Treatment of Cancers: Efficacy of Statin–Dipyridamole Combination Treatment in Melanoma Cell Lines

Biomedicines
Metastatic melanoma has a very poor prognosis. Statins, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) inhibitors, are cholesterol-lowering agents with a potential for cancer treatment.
Nanami Irie, Kana Mizoguchi, Tomoko Warita, Mirai Nakano, Kasuga Sasaki, Jiro Tashiro, Tomohiro Osaki, Takuro Ishikawa, Zoltán N. Oltvai, Katsuhiko Warita   +9 more
doaj   +1 more source