Results 71 to 80 of about 23,943 (202)

Can Stress Echocardiography Compete with Perfusion Scintigraphy in the Detection of Coronary Artery Disease and Cardiac Risk Assessment? [PDF]

, 2000
Aims: The aim of this review was to define the place of stress echocardiography in the context of perfusion scintigraphy for the detection of coronary artery disease (CAD) and the assessment of cardiac risk.
Elhendy, A. (Abdou), Geleijnse, M.L. (Marcel)   +1 more
core   +2 more sources

Effect of Spinacia oleracea on In Vitro Disintegration and Dissolution of Clopidogrel Bisulfate Tablets

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT Drug–food interactions may compromise therapeutic efficacy, particularly for life‐saving medications such as anticoagulants. Changes in gastric fluid properties, including pH modification and surface film formation, can alter drug dissolution and release. This study evaluated a potential interaction between clopidogrel and spinach and explored
Dana Sadaqa, Hani A. Naseef, Asma Radwan, Abdullah K. Rabba, Ramzi H. M. Muqedi   +4 more
wiley   +1 more source

Anti-ischemic therapy and stress testing: pathophysiologic, diagnostic and prognostic implications [PDF]

, 2004
Anti-ischemic therapy, in particular beta-blockers, is the most commonly employed drug for the control of myocardial ischemia in patients with stable coronary artery disease.
Rosa Sicari, E Picano, J Ross Jr, E Picano, BD Beleslin, E Picano, AJ McNeill, E Picano, E Picano, WH Frishman, M Matsusaki, TH Hintze, JS Schwartz, RJ Gibbons, AS Iskandrian, P Steele, B Hockings, GJ Martin, NM Zacca, TH Marwick, JA San Roman, F Lattanzi, N Ferrara, N Ferrara, G Longobardi, PM Fioretti, C Dodi, GA Beller, R Taillefer, J Ross Jr, KP Gallagher, R Sicari, TJ Wang, N Freemantle, TH Marwick, RJ Burns, R Sicari, E Picano, E Picano, L Cortigiani   +39 more
core   +2 more sources

Reprogramming Immunogenicity of Iron Oxide Nanoparticles through Sulfated Glycan Presentation

Small, Volume 22, Issue 11, 20 February 2026.
This study presents a comparative analysis of heparin (HP)‐ and dextran sulfate (DS)‐coated superparamagnetic iron oxide nanoparticles (SPIONs) as a tunable immunomodulatory platform where surface chemistry dictates therapeutic function. DS‐SPIONs are preferentially internalized by myeloid cells, reprogramming them into a pro‐healing M2 phenotype ...
Negin Pournoori, Heela Sarlus, Dick J. Sjöström, Rohith Pavan Parvathaneni, Oommen P. Varghese, Vesa P. Hytönen, Robert A. Harris, Per H. Nilsson, Oommen P. Oommen   +8 more
wiley   +1 more source

Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388) [PDF]

, 2015
RATIONALE: The risk of recurrence following a stroke or transient ischemic attack is high, especially immediately after the event. HYPOTHESIS: Because two antiplatelet agents are superior to one in patients with non-cardioembolic events, more ...
Bath, Philip M.W., Beridze, M., Christensen, H., Dineen, Robert A., Duley, Lelia, Heptinstall, Stan, James, M., Markus, H.S., Nikola, N., Pocock, S, Ranta, A., Robinson, T., TARDIS Trial, Venables, G.   +13 more
core   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Dipyridamole reduces penile apoptosis in a rat model of post-prostatectomy erectile dysfunction

International Brazilian Journal of Urology
Purpose: Despite the nerve-sparing technique, many patients suffer from erectile dysfunction after radical prostatectomy (RP) due to cavernous nerve injury. The aim of this study was to evaluate dipyridamole as a potential treatment agent of post-radical
Omer Kutlu, Ersagun Karaguzel, Ali Ertan Okatan, Ahmet Mentese, Esin Yulug, Ilke Onur Kazaz, Selcuk Kutlu, Eyup Dil, Huseyin Eren, Ahmet Alver   +9 more
doaj   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source

Myocardial fibrosis in stroke survivors [PDF]

, 2015
Stroke survivors are most likely to die of cardiac death, yet few undergo comprehensive cardiac assessment to look for reversible causes. Myocardial fibrosis (MF) is not only the hallmark of cardiomyopathy, but also a substrate for sudden cardiac death ...
Allgar, V., MacWalter, R., McSwiggan, S., Struthers, A. D., Sze, S., Wong, K., Wong, S.   +6 more
core   +1 more source

Repurposing of the Cardiovascular Drug Statin for the Treatment of Cancers: Efficacy of Statin–Dipyridamole Combination Treatment in Melanoma Cell Lines

Biomedicines
Metastatic melanoma has a very poor prognosis. Statins, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) inhibitors, are cholesterol-lowering agents with a potential for cancer treatment.
Nanami Irie, Kana Mizoguchi, Tomoko Warita, Mirai Nakano, Kasuga Sasaki, Jiro Tashiro, Tomohiro Osaki, Takuro Ishikawa, Zoltán N. Oltvai, Katsuhiko Warita   +9 more
doaj   +1 more source