Results 1 to 10 of about 44 (28)

14-Substituted Diquinothiazines as a New Group of Anticancer Agents [PDF]

Molecules, 2023
A series of novel double-angularly condensed diquinothiazines with aminoalkyl, amidoalkyl, sulfonamidoalkyl, and substituted phenyl groups was designed, synthesized, and evaluated for their anticancer activity against four selected human tumor cell lines
Małgorzata Jeleń, Krystian Pluta, Małgorzata Szmielew, Beata Morak-Młodawska, Kinga Herman, Klaudia Giercuszkiewicz, Anna Kasprzycka, Magdalena Skonieczna   +7 more
doaj   +5 more sources

Study of the Lipophilicity and ADMET Parameters of New Anticancer Diquinothiazines with Pharmacophore Substituents [PDF]

Pharmaceuticals
Lipophilicity is one of the principal parameters that describe the pharmacokinetic behavior of a drug, including its absorption, distribution, metabolism, elimination, and toxicity.
Daria Klimoszek, Małgorzata Jeleń, Małgorzata Dołowy, Beata Morak-Młodawska   +3 more
doaj   +6 more sources

Evaluation of the Lipophilicity of Angularly Condensed Diquino- and Quinonaphthothiazines as Potential Candidates for New Drugs [PDF]

Molecules
Lipophilicity is one of the most important properties of compounds required to estimate the absorption, distribution, and transport in biological systems, in addition to solubility, stability, and acid–base nature.
Daria Klimoszek, Małgorzata Jeleń, Beata Morak-Młodawska, Małgorzata Dołowy   +3 more
doaj   +3 more sources

6-[3-(p-Tolyl-sulfonyl-amino)-prop-yl]diquino-thia-zine. [PDF]

Acta Crystallogr Sect E Struct Rep Online, 2013
In the title mol-ecule {systematic name: N-[3-(diquino[3,2-b;2',3'-e][1,4]thia-zin-6-yl)prop-yl]-4-methyl-benzene-sulfon-amide}, C28H24N4O2S2, the penta-cyclic system is relatively planar [maximum deviation from the mean plane = 0.242 (1) Å]. The dihedral angle between two quinoline ring systems is 8.23 (2)° and that between the two halves of the 1,4 ...
Jeleń M, Shkurenko A, Suwińska K, Pluta K, Morak-Młodawska B.   +4 more
europepmc   +4 more sources

Evaluation of angularly condensed diquinothiazines as potential anticancer agents

Bioorganic Chemistry, 2019
© 2019 We present efficient synthesis of isomeric types of angularly fused diquinothiazines in the reactions of 2,2′-dichloro-3,3′-diquinolinyl disulfide and diquinodithiin with 3-, 5-, 6- and 8-aminoquinolines.
Jeleń M., Kuśmierz D., Latocha M., Morak-Młodawska B., Pluta K., Suwińska K.   +5 more
core   +6 more sources

Synthesis of new pentacyclic diquinothiazines

Journal of Heterocyclic Chemistry, 2007
Abstractmagnified imageReactions of 2,2′‐dichloro‐3,3′‐diquinolinyl sulfide 1 with ammonia derivatives and various primary alkylamines and arylamines proceeded as a thiazine ring closure to form linear annulated pentacyclic 6H‐diquinothiazine 2H and 6‐substituted derivatives 2 with alkyl, alkylaryl, aryl and heteroaryl substituents in moderate to good ...
Anthony, Boros, deMeester, Dreikorn, Gupta, Hellberg, Jovanovic, Jovanovic, Jovanovic, Marti, Miao, Nowak, Nowak, Nowak, Pluta, Pluta, Pluta, Pluta, Pluta, Sheldrick, Sheldrick, Smalley, Stahl, Yoshida   +23 more
core   +2 more sources

Study of the lipophilicity of novel diquinothiazines

Journal of Planar Chromatography – Modern TLC, 2007
The lipophilicity of twenty new diquinothiazines has been determined by reversed-phase thin-layer chromatography on RP-18 silica plates with acetone-aqueous TRIS (tris(hydroxymethyl) aminomethane) buffer as mobile phase. The R M values were linearly dependent on the concentration of acetone. The R M0 values were determined by linear extrapolation to 0%
Krystian Pluta, Małgorzata Nowak
core   +2 more sources

Azinyl Sulfides. Part 94. Synthesis of New Pentacyclic Diquinothiazines.

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Kinga Suwinska, Krystian Pluta, Leo Straver, Malgorzata Nowak   +3 more
core   +2 more sources

Synthesis of quinoline/naphthalene-containing azaphenothiazines and their potent in vitro antioxidant properties. [PDF]

Med Chem Res, 2015
Jeleń M, Bavavea EI, Pappa M, Kourounakis AP, Morak-Młodawska B, Pluta K.   +5 more
europepmc   +3 more sources

Fibromatosis-like spindle-cell metaplastic carcinoma of the breast – a case report [PDF]

, 2021
Introduction. Metaplastic breast carcinoma is expressing epithelial and/or mesenchymal tissue within the same tumor. Aim. The aim of this study is to evaluate metaplastic breast carcinoma in a case report and literature review.
Aebisher, David, Bartusik-Aebisher, Dorota, Kaznowska, Ewa, Osuchowski, Michał   +3 more
core   +2 more sources