Results 221 to 230 of about 16,333 (257)

Role of Liver Biopsy in the Era of Direct-Acting Antivirals

Current Gastroenterology Reports, 2013
An accurate assessment of the degree of fibrosis or presence of cirrhosis is critical both for the appropriate management of, and to provide prognosis for, patients with chronic hepatitis C infection. In the new era of direct acting antivirals, large numbers of patients may enter therapy, and although liver biopsy remains the gold standard, it is not ...
Humberto C, Gonzalez, Syed Mohammed, Jafri, Stuart C, Gordon   +2 more
openaire   +2 more sources

[Direct-acting antiviral-resistant variant].

Nihon rinsho. Japanese journal of clinical medicine, 2015
Recently, IFN-free NS5A inhibitor daclatasvir and protease inhibitor asunaprevir combination treatment was approved for genotype 1b HCV-infected patients who were ineligible or who failed to respond to previous therapies. NS5A inhibitor-resistant variants occasionally exist in HCV-infected patients who have never been exposed to direct-acting ...
Michio, Imamura, Kazuaki, Chayama
openaire   +1 more source

IL28B in the Era of Direct-acting Antivirals for Hepatitis C

Journal of Clinical Gastroenterology, 2013
The IL28B genotype is the strongest baseline predictor of hepatitis C treatment response with peginterferon-α and ribavirin. In 2011, 2 protease inhibitors were approved for genotype 1 infection in combination with peginterferon-α and ribavirin, and boceprevir and telaprevir attenuate the association between the IL28B genotype and treatment response ...
openaire   +2 more sources

Direct-acting antivirals for paediatric HCV: we got there

Nature Reviews Gastroenterology & Hepatology, 2017
In a new report, adolescents with genotype 2 or 3 HCV infection who were given sofosbuvir and ribavirin showed a near 100% sustained virologic response. This study is the beginning of a new wave of treatments for paediatric HCV infection, forming part of a global strategy to eradicate viral hepatitis.
openaire   +2 more sources

Direct acting antiviral therapy after liver transplantation

Current Opinion in Gastroenterology, 2016
Historically, postliver transplant patients with chronic hepatitis C have had worse outcomes than nonhepatitis C-related causes because of accelerated fibrosis posttransplantation and the lack of effective well tolerated therapies for hepatitis C, and posttransplant hepatitis C patients have been considered a special population.
openaire   +2 more sources

Direct-acting antiviral treatment for HCV

The Lancet Infectious Diseases, 2016
Stelliana, Goutzamanis, Joseph, Doyle, Alexander, Thompson, Margaret, Hellard, Peter, Higgs   +4 more
openaire   +2 more sources

Direct-Acting Antiviral Agents

Clinics in Liver Disease, 2015
Tatyana Kushner, Vandana Khungar
openaire   +1 more source

Direct-acting antiviral agents for the treatment of HCV

Antiviral Therapy, 2012
Alexander J, Thompson, Stephen, Locarnini   +1 more
openaire   +2 more sources

Direct acting antivirals

Reactions Weekly, 2019
openaire   +1 more source

Direct‐acting antivirals and recurrence of hepatocellular carcinoma

Liver Transplantation, 2017
Jorge A, Marrero, Amit G, Singal
openaire   +2 more sources