Results 61 to 70 of about 4,963,210 (228)

Symmetry in Cascade Chirality-Transfer Processes: A Catalytic Atroposelective Direct Arylation Approach to BINOL Derivatives.

Journal of the American Chemical Society, 2016
Herein we disclose a scalable organocatalytic direct arylation approach for the regio- and atroposelective synthesis of non-C2-symmetric 2,2'-dihydroxy-1,1'-binaphthalenes (BINOLs). In the presence of catalytic amounts of axially chiral phosphoric acids,
Jinzheng Wang, Jin Zhou, Changzhu Xu, Hongbin Sun, Laszlo Kuerti, Qinglong Xu   +5 more
semanticscholar   +1 more source

Hydrodehalogenation of Aryl Halides through Direct Electrolysis [PDF]

Chemistry – A European Journal, 2019
AbstractA catalyst‐ and metal‐free electrochemical hydrodehalogenation of aryl halides is disclosed. Our reaction by a flexible protocol is operated in an undivided cell equipped with an inexpensive graphite rod anode and cathode. Trialkylamines nBu3N/Et3N behave as effective reductants and hydrogen atom donors for this electrochemical reductive ...
Jie Ke, Hongling Wang, Liejin Zhou, Chengli Mou, Jingjie Zhang, Lutai Pan, Yonggui Robin Chi   +6 more
openaire   +4 more sources

Pd‐Catalyzed C─C Bond Borylation of Biphenylenes Leading to Tri‐Ortho‐Substituted Biaryls

Chemistry – A European Journal, EarlyView.
Palladium‐catalyzed ring‐opening C─C borylation of 1‐substituted biphenylenes yields a range of o,o,o′‐trisubstituted biaryls with two ortho‐boryl groups via selective cleavage of the least hindered C─C bond. The resulting diborylated products are readily amenable to sequential, site‐selective postfunctionalization.
Robyn V. Presland, Konstantin V. Luzyanin, Luke A. Wilkinson, Oliver L. Jacobs, Nathan R. Halcovitch, Alexey G. Sergeev   +5 more
wiley   +1 more source

Desymmetrization of Malonic Monoesters and Malonic Acids via Enantioselective Catalytic C(sp3)─H Oxidation

Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.
Manganese‐catalyzed enantioselective C(sp3)─H lactonization with hydrogen peroxide enables the direct desymmetrization of malonic monoesters and malonic acids, providing highly enantioenriched γ‐ and δ‐lactones (up to >99% ee) ABSTRACT Malonate derivatives are readily available starting materials widely employed in the synthesis of bioactive compounds.
Nikos Siakavaras, Arnau Call, Massimo Bietti, Miquel Costas   +3 more
wiley   +2 more sources

Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp3)–H arylation

Beilstein Journal of Organic Chemistry, 2016
The synthesis of β-arylated alkylamides via alkyl C–H bond arylation has been realized by means of direct one-pot reactions of acyl chlorides, aryl iodides and 8-aminoquinoline. Depending on the structure of the starting materials, both single and double
Yunyun Liu, Yi Zhang, Xiaoji Cao, Jie-Ping Wan   +3 more
doaj   +1 more source

Practical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H2O-mediated H2 evolution

Nature Communications, 2021
2-(hetero)aryl N-heteroarenes are ubiquitously applied in numerous fields of science and useful for the development of bioactive molecules and drugs, but there is a lack of general methods for their synthesis.
Liang Cao, He Zhao, Rongqing Guan, Huanfeng Jiang, Pierre. H. Dixneuf, Min Zhang   +5 more
doaj   +1 more source

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

Chemistry – A European Journal, EarlyView.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

Palladium-Catalyzed Arylations towards 3,6-Diaryl-1,3a,6a-triazapentalenes and Evaluation of Their Fluorescence Properties

Molecules
Methyl 4-(1,3a,6a-triazapentalen-3-yl)benzoate (TAP1) shows interesting properties as a small molecule fluorophore. In the search for post-functionalization methods, palladium-catalyzed arylation reactions were demonstrated. Direct CH arylation reactions
Yingchun Wang, Tomas Opsomer, Flip de Jong, Davy Verhaeghe, Maarten Mulier, Luc Van Meervelt, Mark Van der Auweraer, Wim Dehaen   +7 more
doaj   +1 more source

Dihydroquinazolinones by Titanocene‐Catalyzed Reductive Radical Addition to Quinazolinones

Chemistry – A European Journal, EarlyView.
Tri‐ and tetracyclic dihydroquinazolinones or quinazolinones by titanocene catalysis: A highly diastereoselective and efficient reductive radical addition to quinazolinones enables an unprecedented entry to pharmaceutically relevant dihydroquinazolinones by avoiding the interception of radical intermediates prior to the slow radical addition.
Thomas Heinrichs, Fabian Lang, Konstantin Woitol, Jana Vohn, Andreas Schneider, Andreas Gansäuer   +5 more
wiley   +1 more source

Arylhydrazines: Convenient Homogeneous Reductants for Scalable Cross‐Coupling

Angewandte Chemie, Volume 138, Issue 12, 16 March 2026.
Reductive cross‐couplings enable efficient C–C bond formation but are limited by the heterogeneity of Zn or costly reagents like TDAE. We report arylhydrazines as inexpensive, convenient reductants for Ni‐catalyzed sp2–sp3 coupling of aryl halides and secondary alkyl iodides. Mechanistic studies support hydrazine‐mediated NiII reduction for a NiI/NiIII
Nils Kurig, David A. Cagan, Kaid C. Harper, Yu Kawamata, Donna G. Blackmond, Phil S. Baran   +5 more
wiley   +2 more sources