Results 131 to 140 of about 678,742 (284)

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento   +3 more
wiley   +1 more source

Comparison of granulated lactose properties produced by various wet granulation methods without the use of binders

open access: yesРазработка и регистрация лекарственных средств
Introduction. Direct compression is one of the most preferred methods for the production of tablet dosage forms in terms of efficiency, since it allows you to minimize the technological process down to the level of "mixing-tableting-filling and packaging"
A. E. Baldaev   +4 more
doaj   +1 more source

FOREIGN DIRECT INVESTMENT: LOCALIZATION AND INSTITUTIONAL DETERMINANTS [PDF]

open access: yes
This article examines the foreign direct investment (FDI) in Portugal, i.e why foreign companies are located in Portugal. The compression of the determinants of FDI is important to take decisions on economic policy.
Nuno Carlos LEITÃO
core  

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak   +4 more
wiley   +1 more source

Process Modeling and Simulation of Tableting-An Agent-Based Simulation Methodology for Direct Compression. [PDF]

open access: yesPharmaceutics, 2021
Martin NL   +5 more
europepmc   +1 more source

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons   +33 more
wiley   +1 more source

Continuous direct compression: Development of an empirical predictive model and challenges regarding PAT implementation. [PDF]

open access: yesInt J Pharm X, 2022
Bekaert B   +7 more
europepmc   +1 more source

EntroGD: Efficient Compression and Accurate Direct Analytics on Compressed Data

open access: yes
Generalized Deduplication (GD) enables lossless compression with direct analytics on compressed data by dividing data into \emph{bases} and \emph{deviations} and performing dictionary encoding on the former. However, GD algorithms face scalability challenges for high-dimensional data.
Zhao, Xiaobo, Lucani, Daniel E.
openaire   +2 more sources

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan   +5 more
wiley   +1 more source

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