Results 51 to 60 of about 678,742 (284)

The Role of the Geometric Configuration of Diethylaminoethanol Derivative in the Pharmaceutical Development of a Dosage Form Based on It

Разработка и регистрация лекарственных средств, 2023
Introduction. A comprehensive study of the active pharmaceutical ingredient (API) molecule is one of the defining criteria for pharmaceutical development according to the Quality by Design (QbD) concept and the ICH Q8 framework.
Yu. M. Kotsur, K. M. Tserkovnaya, E. V. Flisyuk, I. A. Titovich, K. O. Sidorov, I. A. Narkevich   +5 more
doaj   +1 more source

Heterogeneity in structurally arrested hard spheres [PDF]

, 2008
When cooled or compressed sufficiently rapidly, a liquid vitrifies into a glassy amorphous state. Vitrification in a dense liquid is associated with jamming of the particles. For hard spheres, the density and degree of order in the final structure depend
An, Li-Jia, Li, Zi-Qi, Sun, Zhao-Yan, Wang, Zhen-Gang   +3 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Enhancing paracetamol compressibility using the co-drying technique: Impact on tablet release profile from direct compression

German Journal of Pharmaceuticals and Biomaterials
Direct compression is the most acceptable and preferred method for manufacturing tablets. However, the poor flow property and lack of the required compressibility of most active ingredients preclude the direct compression technique.
Shreya Sham Naik, Sandesh Narayan Somnache, Ajeet Madhukar Godbole, Clecy Fernandes   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Formulation, characterization, and evaluation of orodispersible tablet of a model antidepressant drug

Indian Journal of Health Sciences and Biomedical Research KLEU, 2016
Introduction: Paroxetine hydrochloride is used as the antidepressant drug of the selective serotonin reuptake inhibitor. It is used to treat depression resistant to other antidepressants, depression complicated by anxiety, panic disorder, obsessive ...
V G Jamakandi, Chetan Prakash Kalsannavar, S P Hiremath, F S Dasanakoppa, S S Kerur   +4 more
doaj   +1 more source

Prediction of the composition of prolonged release tablets based on 4,4'-(propandiamido) sodium dibenzoate using the SeDeM method

Разработка и регистрация лекарственных средств, 2021
Introduction. Direct compression technology is one of the most common tablet technologies. As known, many active pharmaceutical ingredients are not suitable for this technology without the addition of special excipients. A useful tool for determining the
Ju. M. Kotsur, Ju. M. Ladytko, I. A. Narkevich, E. V. Flisyuk   +3 more
doaj   +1 more source

The effects of quenching and aging on the mechanical and physical properties of recycled aa6061 aluminum chips [PDF]

, 2017
At present, the usage of aluminum is widely used. The recycling process is needed to respond to the government's call for a green earth campaign cause of the lack of mineral resources on this earth.
Dongdong Zhang, Hui Hwang Goh, Kai Chen Goh, Kimlin Saing, Tonni Agustiono Kurniawan, Wei Dai   +5 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Improving Tableting Performance of Lactose Monohydrate by Fluid-Bed Melt Granulation Co-Processing

Pharmaceutics, 2021
Co-processing is commonly used approach to improve functional characteristics of pharmaceutical excipients to become suitable for tablet production by direct compression.
Djordje Medarević, Jelena Djuriš, Mirjana Krkobabić, Svetlana Ibrić   +3 more
doaj   +1 more source