Results 181 to 190 of about 3,445,632 (296)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Direct detection of 8-oxo-dG using nanopore sequencing. [PDF]

Nat Commun
Pagès-Gallego M, van Soest DMK, Besselink NJM, Straver R, Keijer JP, Vermeulen C, Marcozzi A, van Roosmalen MJ, van Boxtel R, Burgering BMT, Dansen TB, de Ridder J.   +11 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Evaluation of an automated molecular diagnostic instrument for direct detection of <i>Burkholderia pseudomallei</i> from clinical specimens. [PDF]

J Med Microbiol
Gassiep I, Glover M, Beecham M, Gorman B, Page M, Stewart J, Harris PNA.   +6 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Analytical performance of the Xpert Carba-R assay for direct detection of carbapenemase genes in respiratory specimens from hospitalized patients: a multicenter evaluation in China. [PDF]

Front Microbiol
Li K, Liu Y, Yao Y, Wang J, Hui Y, Li J, Luo X, Gao X, Tang YW, Wei L.   +9 more
europepmc   +1 more source

Direct detection of atomic oxygen on the dayside and nightside of Venus. [PDF]

Nat Commun, 2023
Hübers HW, Richter H, Graf UU, Güsten R, Klein B, Stutzki J, Wiesemeyer H.   +6 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Quantification of subcellular RNA localization through direct detection of RNA oxidation [PDF]

Nucleic Acids Res
Lo HG, Goering R, Kocere A, Lo J, Pockalny MC, White LK, Ramirez H, Martinez A, Jacobson S, Spitale RC, Pearson CG, Resendiz MJE, Mosimann C, Taliaferro JM.   +13 more
europepmc   +2 more sources

Direct detection of Gram-negative bacilli and extended-spectrum β-lactamase producers in positive blood culture specimens using MALDI-TOF MS. [PDF]

Front Cell Infect Microbiol
Kosai K, Kawamoto Y, Mitsumoto-Kaseida F, Kaku N, Hasegawa H, Takazono T, Izumikawa K, Mukae H, Yanagihara K.   +8 more
europepmc   +1 more source