Results 61 to 70 of about 588,717 (296)

Direction dependency in coaxial laser double wire Direct Energy Deposition

Procedia CIRP, 2022
Coaxial Laser wire Direct Energy Deposition (L-DED) promises a direction-independent buildup due to a centric supply of the welding material. To fabricate Functionally Graded Materials (FGMs), a processing head was designed that is capable of supplying two wire materials into the processing zone.
Schwarz, Nick, Lammers, Marius, Hermsdorf, Jörg, Kaierle, Stefan, Ahlers, Henning, Lachmayer, Roland   +5 more
openaire   +3 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Effect of auxiliary wire feeding on cold metal transfer directed energy deposition of stainless steel: A study on droplet transfer, formation characteristics, and microstructure

Journal of Materials Research and Technology
While traditional cold metal transfer direct energy deposition (T-CMT-DED) can be sped up by increasing the deposition current; this often negatively affects the deposited part's shape and microstructure due to increased heat input.
Yi Feng, Qiming Jiang, Ding Fan
doaj   +1 more source

Influence of Tungsten Addition on Microstructure and Tensile Properties of Ti6Al4V Fabricated by Laser-Directed Energy Deposition

Metals, 2023
The addition of tungsten can improve the high-temperature oxidation resistance of titanium alloys. However, as its applications continue to expand, new demands are being placed on its room temperature strength.
Junguo Li, Jinding Xiong, Yi Sun, Qinqin Wei   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Effect of Direct Energy Deposition Process Parameters on Single-Track Deposits of Alloy 718

Metals, 2020
The effect of three important process parameters, namely laser power, scanning speed and laser stand-off distance on the deposit geometry, microstructure and segregation characteristics in direct energy deposited alloy 718 specimens has been studied ...
Suhas Sreekanth, Ehsan Ghassemali, Kjell Hurtig, Shrikant Joshi, Joel Andersson   +4 more
doaj   +1 more source

Cosmic microwave background constraints on light dark matter candidates

, 2013
Unveiling the nature of cosmic dark matter (DM) is an urgent issue in cosmology. Here we make use of a strategy based on the search for the imprints left on the cosmic microwave background temperature and polarization spectra by the energy deposition due
Evoli, Carmelo, Ferrara, Andrea, Pandolfi, Stefania   +2 more
core   +1 more source

The origin of defects induced in ultra-pure germanium by Electron Beam Deposition [PDF]

, 2015
The creation of point defects in the crystal lattices of various semiconductors by subthreshold events has been reported on by a number of groups. These observations have been made in great detail using sensitive electrical techniques but there is still ...
A Einstein, AJ Sievers, AM Kosevich, DV Lang, E Reinhold, F Piazza, FD Auret, FD Auret, FM Russell, HA Klose, JA Naber, JF Ziegler, JFR Archilla, JFR Archilla, JFR Archilla, L Dobaczewski, NW Ashcroft, RS MacKay, SZ Karazhanov, VI Dubinko, VI Dubinko, W Bauer, Y Chen   +22 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The Corrosion Behavior of 316L Stainless Steel Additively Manufactured by Direct Energy Deposition Process

Materials Proceedings, 2021
Traditional additive manufacturing (AM) technologies tend to focus on powder bed fusion (PBF) methods, such as SLM (selective laser melting) and EBM (electron beam melting), that are attractive for the rapid production of complex components.
Tomer Ron, Avi Leon, Amnon Shirizly, Eli Aghion   +3 more
doaj   +1 more source