Results 61 to 70 of about 176,367 (302)

Linear support structures made of glass using additive manufacturing

Discover Mechanical Engineering
The increasing demand for large-scale, lightweight, and aesthetically customizable glass facades in modern architecture requires new approaches to enhance the mechanical performance of the used glass elements.
Franz Hesse, Andreas Herrmann, Jörg Hildebrand, Jean Pierre Bergmann   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Partitioning of laser energy during directed energy deposition

Additive Manufacturing, 2017
Abstract An energy balance that describes the transfer of energy is proposed for the laser-based directed energy deposition process. The partitioning of laser energy was experimentally measured and accurately validated using a special process calorimeter for Ti-6Al-4V and Inconel 625™ alloys. The total energy provided by the laser was partitioned as:
Frederick Lia, Joshua Park, Jay Tressler, Richard Martukanitz   +3 more
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Effect of auxiliary wire feeding on cold metal transfer directed energy deposition of stainless steel: A study on droplet transfer, formation characteristics, and microstructure

Journal of Materials Research and Technology
While traditional cold metal transfer direct energy deposition (T-CMT-DED) can be sped up by increasing the deposition current; this often negatively affects the deposited part's shape and microstructure due to increased heat input.
Yi Feng, Qiming Jiang, Ding Fan
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

In-situ high-dynamic micro hammering enhanced wire-arc direct energy deposition of magnesium alloy

Journal of Magnesium and Alloys
Wire-arc direct energy deposition (WA-DED) has emerged as a suitable solution for the rapid manufacturing of magnesium (Mg) alloys, and the in-situ improvement of the microstructure and properties is essential to promote its further application.
Zhifei Xu, Jun Xiao, Shujun Chen, Chao Ding, Shengnan Gai, Zhaoyang Yan   +5 more
doaj   +1 more source

Effect of Direct Energy Deposition Process Parameters on Single-Track Deposits of Alloy 718

Metals, 2020
The effect of three important process parameters, namely laser power, scanning speed and laser stand-off distance on the deposit geometry, microstructure and segregation characteristics in direct energy deposited alloy 718 specimens has been studied ...
Suhas Sreekanth, Ehsan Ghassemali, Kjell Hurtig, Shrikant Joshi, Joel Andersson   +4 more
doaj   +1 more source

Design Considerations for a Directed Energy Deposition Cell

, 2023
Setting up a robotised additive manufacturing machine requires attention to several safety aspects, including integration of different systems, a functional work area, human-machine interfaces and convenience in operation. This article presents some topics that should be considered in the design and assembly of a cell for robotised additive ...
Hassel, Trond Arne, Brøtan, Vegard, Sørby, Knut   +2 more
openaire   +3 more sources

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source