Results 131 to 140 of about 2,076,692 (292)

Direct imaging of micrometer-thick interfaces in salt-salt aqueous biphasic systems. [PDF]

Proc Natl Acad Sci U S A, 2023
Degoulange D, Pandya R, Deschamps M, Skiba DA, Gallant BM, Gigan S, de Aguiar HB, Grimaud A.   +7 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

JWST/NIRCam Imaging of Young Stellar Objects. II. Deep Constraints on Giant Planets and a Planet Candidate Outside of the Spiral Disk Around SAO 206462

The Astronomical Journal
We present JWST/NIRCam F187N, F200W, F405N, and F410M direct imaging data of the disk surrounding SAO 206462. Previous images show a very structured disk, with a pair of spiral arms thought to be launched by one or more external perturbers.
Gabriele Cugno, Jarron Leisenring, Kevin R. Wagner, Camryn Mullin, Ruobing Dong, Thomas Greene, Doug Johnstone, Michael R. Meyer, Schuyler G. Wolff, Charles Beichman, Martha Boyer, Scott Horner, Klaus Hodapp, Doug Kelly, Don McCarthy, Thomas Roellig, George Rieke, Marcia Rieke, John Stansberry, Erick Young   +19 more
doaj   +1 more source

Direct Imaging of Local pH Reveals Bubble-Induced Mixing in a CO₂ Electrolyzer. [PDF]

ACS Sustain Chem Eng, 2023
Baumgartner LM, Kahn A, Hoogland M, Bleeker J, Jager WF, Vermaas DA.   +5 more
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

An Improved Bio-Orientation Method Based on Direct Sunlight Compensation for Imaging Polarization Sensor

Journal of Imaging
Direct sunlight in complex environmental conditions severely interferes with the light intensity response for imaging Polarization Sensor (PS), leading to a reduction in polarization orientation accuracy.
Guangmin Li, Ya Zhang, Shiwei Fan, Fei Yu   +3 more
doaj   +1 more source

Systemic Delivery of Divalent Europium from Ligand Screening with Implications to Direct Imaging of Hypoxia. [PDF]

J Am Chem Soc, 2022
Rashid MM, Corbin BA, Jella P, Ortiz CJ, Hassan Samee MA, Pautler RG, Allen MJ.   +6 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Direct imaging of local atomic structures in zeolite using optimum bright-field scanning transmission electron microscopy. [PDF]

Sci Adv, 2023
Ooe K, Seki T, Yoshida K, Kohno Y, Ikuhara Y, Shibata N.   +5 more
europepmc   +1 more source