Results 121 to 130 of about 1,136,956 (309)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Towards dynamic camera calibration for constrained flexible mirror imaging [PDF]
, 2008 Flexible mirror imaging systems consisting of a perspective camera viewing a scene reflected in a flexible mirror can provide direct control over image field-of-view and resolution. However, calibration of such systems is difficult due to the vast range
Dunne, Aubrey K. +2 more
core
Direct 4D Parametric Imaging in Dynamic Myocardial Perfusion PET
Frontiers in Biomedical Technologies, 2014 Purpose: Dynamic myocardial perfusion (MP) PET imaging followed by tracer kinetic modeling allows quantification of myocardial blood flow, thus enabling computation of the coronary flow reserve, with considerable clinical potentials.
Arman Rahmim +2 more
doaj
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Millimetre wave imaging for concealed target detection
, 2011 PhDConcealed weapon detection (CWD) has been a hot topic as the concern about pub- lic safety increases. A variety of approaches for the detection of concealed objects on the human body based on earth magnetic ¯eld distortion, inductive magnetic ¯eld,
Zhang, Lianhong
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Direct imaging of electron density with a scanning transmission electron microscope. [PDF]
Nat Commun, 2023 Dyck O +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A synchronised Direct Digital Synthesiser
, 2005 We describe a Direct Digital Synthesiser (DDS) which provides three frequency-locked synchronised outputs to generate frequencies from DC to 160 MHz. Primarily designed for use in a heterodyning range imaging system, the flexibility of the design allows ...
Payne, Andrew D. +3 more
core