Results 51 to 60 of about 240,744 (220)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Non-existence, radial symmetry, monotonicity, and Liouville theorem of master equations with fractional p-Laplacian

Advances in Nonlinear Analysis
In this article, first, we introduce a new operator (∂t−Δp)su(z,t)=Cn,sp∫−∞t∫Rn∣u(z,t)−u(ζ,ϱ)∣p−2(u(z,t)−u(ζ,ϱ))(t−ϱ)n2+1+sp2e−∣z−ζ∣24(t−ϱ)dζdϱ,{\left({\partial }_{t}-{\Delta }_{p})}^{s}u\left(z,t)={C}_{n,sp}\underset{-\infty }{\overset{t}{\int }}\mathop{
Liu Mengru, Zhang Lihong
doaj   +1 more source

Relevance of Ion-Channeling for Direct DM Detection

, 2009
The channeling of the recoiling nucleus in crystalline detectors after a WIMP collision would produce a larger scintillation or ionization signal in direct detection experiments than otherwise expected.
Avignone F T, Bozorgnia N, Graciela B Gelmini, Górski K M, KKomaki el al, Lindhard J   +5 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Simulation of thermal processes in a half-space under heating by a moving source with a uniformly distributed heat flow

Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук
Using the method of applying instantaneous point sources, a solution was obtained to the problem of heat conduction during surface heating of a body in the form of a half-space by a uniformly distributed highly concentrated heat flux moving at a constant
A. V. Verameichyk, B. G. Kholodar
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Tectonic Evolution of the Intra-plate Structures of Sarmatia in the Phanerozoic. 2. Tectonic frameworks of deformations

Вісник Харківського національного університету імені В.Н. Каразіна. Серія Геологія. Географія. Екологія
Objective. Based on data from the Dnieper-Donetsk Aulacogene, the role of different-age systems of crustal faults as tectonic frameworks of deformations of the Sarmatian plate was investigated. Methods.
Oleksii Bartaschuk, Vasyl Suyarko, Oleksandr Chuienko   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source