Results 51 to 60 of about 175,047,704 (220)

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Moving IRBFN-based Integration-Free Meshless Method [PDF]

, 2010
A novel approximation method using integrated radial basis function networks (IRBFN) coupled with moving least square (MLS) approximants, namely moving integrated radial basis function networks (MIRBFN), is proposed in this work.
Le, Phong B. H., Nam Mai-Duy, Rabczuk, Timon, Mai-Duy, Nam, Phong B.H. Le, Timon Rabczuk, Thanh Tran-Cong, Tran-Cong, Thanh   +7 more
core   +1 more source

Moving mesh methods for solving parabolic partial differential equations [PDF]

, 2010
In this thesis, we introduce and assess a new adaptive method for solving non-linear parabolic partial differential equations with fixed or moving boundaries, using a moving mesh with continuous finite elements.
Marlow, Robert
core   +1 more source

A semilinear Dirichlet problem involving the fractional Laplacian in R+ n

Advanced Nonlinear Studies
We investigate the Dirichelt problem involving the fractional Laplacian in the upper half-space R+n=x∈Rn∣x1>0 ${\mathbb{R}}_{+}^{n}=\left\{x\in {\mathbb{R}}^{n}\mid {x}_{1}{ >}0\right\}$ :  (−Δ)su(x)=f(u(x)),x∈R+n, u(x)>0,x∈R+n, u(x)=0,x∉R+n.
Li Yan
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Inclination of the orbital planes of visual binaries [PDF]

, 1998
The inclination of the orbital planes of 78 visual binaries with known orbits with respect to the galactic was examined. No double star groupings were found having approximately equal orientation of their orbital planes. Viewed the orbital plane
Popović G.M., G.M. Popovic
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source