Results 51 to 60 of about 95,386 (312)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Near-Field Aeroacoustics of Spanwise Forcing on a Transonic Wing: A DNS Study

Applied Sciences
The transonic airflow around a supercritical wing with a shock wave is described via direct numerical simulations. Flow control for turbulent drag reduction is applied via streamwise traveling waves of spanwise velocity applied on a finite portion of the
Niccolò Berizzi, Davide Gatti, Giulio Soldati, Sergio Pirozzoli, Maurizio Quadrio   +4 more
doaj   +1 more source

Experimentation and direct numerical simulation of self-similar convergent detonation wave

EPJ Web of Conferences, 2011
The propagation of self similar convergent detonation wave in TATB-based explosive composition was studied both experimentally and numerically. The device constists in a 50 mm cylinder of TATB surrounded by an HMX tube.
Bozier O., Matignon C., Sorin R.
doaj   +1 more source

Advanced Techniques used in Numerical Simulation for Deep-drawing Process [PDF]

MATEC Web of Conferences, 2019
The present paper analyse the main characteristics of the numerical simulation by finite element method of the deep-drawing processes. Also the authors’ highlights the mathematical apparatus and the calculus method used for numerical simulations of metal
Oleksik Valentin, Breaz Radu, Racz Gabriel, Dan Brindasu Paul, Bologa Octavian   +4 more
doaj   +1 more source

Direct numerical simulation of axisymmetric turbulence [PDF]

Physical Review Fluids, 2017
The dynamics of decaying strictly axisymmetric, incompressible turbulence is investigated using direct numerical simulations. It is found that the angular momentum is a robust invariant of the system. It is further shown that long-lived coherent structures are generated by the flow, associated with stationary solutions of the Euler equations.
Qu, Bo, Bos, Wouter J.T., Naso, Aurore
openaire   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Low Reynolds Number Flow Around Tori of Different Slenderness Γ

Applied Sciences, 2017
We present the results of axisymmetric and three-dimensional numerical simulations of the flow around a torus in the low Reynolds number regime [ 10 − 2 ; 3 × 10 3 ] and aspect-ratio 0 < Γ = 2 a / R ≤ 2 (core diameter ...
Werner M. J. Lazeroms, Marco D. de Tullio, Nicola De Santis, Roberto Pizzoferrato, Roberto Verzicco   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source