Results 51 to 60 of about 1,055,399 (260)

Direct Tracking of the Pareto Front of a Multi-Objective Optimization Problem

Journal of Marine Science and Engineering, 2020
In this paper, some methodologies aimed at the identification of the Pareto front of a multi-objective optimization problem are presented and applied. Three different approaches are presented: local sampling, Pareto front resampling and Normal Boundary ...
Daniele Peri
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Approximation Algorithms for Directed Steiner Problems

Journal of Algorithms, 1999
Summary: The authors give the first nontrivial approximation algorithms for the Steiner tree problem and the generalized Steiner network problem on general directed graphs. These problems have several applications in network design and multicast routing. For both problems, the best ratios known before their work were the trivial \(O(k)\)-approximations.
Moses Charikar, Chandra Chekuri, To-Yat Cheung, Zuo Dai, Ashish Goel, Sudipto Guha, Ming Li 0001   +6 more
openaire   +3 more sources

Migración mediante apilado por difracción en medios con gradiente constante de velocidad

Earth Sciences Research Journal, 2001
<p class="MsoNormal" style="line-height: normal; margin: 0cm 0cm 0pt; mso-layout-grid-align: none;"><span style="font-family: ";Arial";,";sans-serif";; font-size: 12pt; mso-ansi-language: EN-US;" lang="EN-US">In order to investigate the ...
Castillo López Luis Antonio
doaj  

Analytical Solutions for Direct and Inverse Source Problems in a Time-Fractional Diffusion Equation

Mathematics
This investigation is concerned with a time-fractional diffusion equation governed by the Hilfer fractional derivative of order ...
Ghaziyah Alsahli, Nura Alotaibi, Sid Ahmed Ould Beinane, Asim Ilyas   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Solutions of Direct Geodetic Problem in Navigational Applications [PDF]

TransNav, 2011
Solutions of such navigational problems as positions from ranges, bearings and courses without any simplifications for a plane or a sphere, by an application of solutions of direct geodetic problem are pre-sented.
Andrzej Lenart
doaj  

Effect of Problem-Based Learning Model and Motivation toward Learning Outcomes on Network Routing

Jurnal Pendidikan Teknologi dan Kejuruan, 2018
This study explored the effect of problem-based learning and motivation toward learning outcomes of the subject of computer routing network. Computer routing network is part of the subject of computer network design in a computer network engineering ...
Kurnia Dwi Ariyanti, Aye Aye Mon, Ekohariadi Ekohariadi, Lilik Anifah   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source