Results 31 to 40 of about 1,055,399 (260)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
The code problem for directed figures [PDF]
RAIRO - Theoretical Informatics and Applications, 2010 Summary: We consider directed figures defined as labelled polyominoes with designated start and end points, with two types of catenation operations. We are especially interested in codicity verification for sets of figures, and we show that depending on the catenation type the question whether a given set of directed figures is a code is decidable or ...
openaire +3 more sources
Solving a directed-percolation inverse problem
Physical Review E, 2022 We present a directed percolation inverse problem for diode networks: Given information about which pairs of nodes allow current to percolate from one to the other, can one find a configuration of diodes consistent with the observed currents? We implement a divide-and-concur iterative projection method for solving the problem and demonstrate the ...
openaire +3 more sources
Join-Reachability Problems in Directed Graphs [PDF]
Theory of Computing Systems, 2011 For a given collection G of directed graphs we define the join-reachability graph of G, denoted by J(G), as the directed graph that, for any pair of vertices a and b, contains a path from a to b if and only if such a path exists in all graphs of G. Our goal is to compute an efficient representation of J(G).
Loukas Georgiadis +2 more
openaire +6 more sources
A Solution Method for Direct and Inverse Problems of an Electromagnet Magnetic Circuit
IEEE AccessThis paper presents a unified computational framework for solving the direct and inverse problems of a lifting electromagnet using a magnetic equivalent circuit (MEC) method.
Areg Grigoryan +4 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Semi-analytical implicit direct time integration method for 1-D gas dynamic problem
Mechanics and Advanced Technologies, 2023 Sharp wave treatment for 1-D gas dynamic problem is still a chellenge for modern numerical methods. They often require too many space and time steps, produce spurious oscillation of solution, exhibit a strong numerical dissipation or divergence of ...
Igor Orynyak +2 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source