Results 41 to 50 of about 1,055,399 (260)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Splitting Problem for Coalgebras: A Direct Approach [PDF]
Applied Categorical Structures, 2006 Original paper appeared in Appl. Cat. Struct. 14, no.
openaire +3 more sources
Identification of a Mathematical Model of Economic Development of Two Regions of the World
Известия Иркутского государственного университета: Серия "Математика"This paper is devoted to solving the inverse problem (determining the parameters of a system of ordinary differential equations based on additional information determined at discrete points in time) and analyzing its solution for a mathematical model ...
M. V. Bezgachev +2 more
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Reachability Problems on Directed Graphs [PDF]
, 2008 I will present recent work and open problems on two directed graph reachability problems, one dynamic, one static. The dynamic problem is to detect the creation of a cycle in a directed graph as arcs are added. Much progress has been made recently on this problem, but intriguing questions remain.
openaire +1 more source
On the cardinality of subsequence sums II
Comptes Rendus. MathématiqueLet $A=(\underbrace{a_1,\ldots ,a_1}_{r_1},\underbrace{a_2,\ldots ,a_2}_{r_2},\ldots ,\underbrace{a_k,\ldots ,a_k}_{r_k})$ be a finite sequence of integers with ...
Jiang, Xing-Wang, Li, Ya-Li
doaj +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
IEEE Access, 2020 The tool-path problem has been extensively studied in manufacturing technologies, as it has a considerable impact on production time. Additive manufacturing is one of these technologies; it takes time to fabricate parts, so the selection of optimal tool ...
Maialen Murua +3 more
doaj +1 more source