Results 241 to 250 of about 3,674,005 (341)

Pathway selection between click and acyl transfer reactions driven by aminoacyl phosphates. [PDF]

Nat Commun
Bhattacharjee D, Sharma A, Dai K, Pramod T, Saile L, Thomann R, Pappas CG.   +6 more
europepmc   +1 more source

A direct interaction between a DNA-tracking protein and a promoter recognition protein: implications for searching DNA sequence.

, 1996
Rachel Tinker-Kulberg, Tsu-Ju Fu, E. Peter Geiduschek, George A. Kassavetis   +3 more
openalex   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Comprehensive mapping of RNA modification dynamics and crosstalk via deep learning and nanopore direct RNA-sequencing. [PDF]

Nat Commun
Dong H, Gao Y, Cai Z, Li Y, Li X, Zhao F, Zhang J.   +6 more
europepmc   +1 more source

Neural sequences underlying directed turning in Caenorhabditis elegans

Talya S Kramer, Flossie K. Wan, Sarah Pugliese, Adam Atanas, Sreeparna Pradhan, Alex W. Hiser, Lillie Godinez, Jinyue Luo, Eric Bueno, Thomas E. Felt, Steven W. Flavell   +10 more
openalex   +1 more source

Direct sequencing by thermal asymmetric PCR

Nucleic Acids Research, 1991
G R, Mazars, C, Moyret, P, Jeanteur, C G, Theillet   +3 more
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Genomic language model mitigates chimera artifacts in nanopore direct RNA sequencing. [PDF]

Nat Commun
Li Y, Wang TY, Guo Q, Ren Y, Lu X, Cao Q, Yang R.   +6 more
europepmc   +1 more source

Transferrin-Binding Protein B of Neisseria meningitidis : Sequence-Based Identification of the Transferrin-Binding Site Confirmed by Site-Directed Mutagenesis

, 2004
Geneviève Renauld‐Mongénie, Laurence Lins, Tino Krell, Laure Laffly, M Mignon, Monique Dupuy, Rose-May Delrue, Françoise Guinet-Morlot, Robert Brasseur, Ling Lissolo   +9 more
openalex   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source