Results 81 to 90 of about 1,309,317 (348)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Le discours direct dans la presse : une approche didactique

open access: yesE-REA, 2019
This paper offers a synthesis of recent research works focusing on direct reported speech used in the British press. Thanks to a didactic approach, it aims to analyse the way reported words are inserted into newspaper articles.
Grégoire LACAZE
doaj   +1 more source

THE CHILD AND THE WORLD: How Children acquire Language [PDF]

open access: yes, 2005
HOW CHILDREN ACQUIRE LANGUAGE Over the last few decades research into child language acquisition has been revolutionized by the use of ingenious new techniques which allow one to investigate what in fact infants (that is children not yet able to speak)
Allott, Robin
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Towards a vividness in synthesized speech for audiobooks

open access: yesEesti ja Soome-ugri Keeleteaduse Ajakiri, 2019
The goal of this study was to determine which acoustic parameters are significant in differentiating the speaking styles of a narrator and that of male and female characters as voiced by a reader of audiobooks.
Hille Pajupuu, Rene Altrov, Jaan Pajupuu
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Transformative Poetry. A General Introduction and a Case Study of Psalm 2

open access: yesPerichoresis: The Theological Journal of Emanuel University, 2016
The structure of Psalm 2 is based on direct speeches in the text. These direct speeches characterise the communication that takes place in the text. The text-immanent author addresses the text-immanent reader with a question in the first line and with a ...
Wieringen Archibald L. H. M. van
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Coding Anger in Fiction

open access: yesActa Universitatis Carolinae: Philologica, 2017
The paper examines the fictional representation of anger in English. The emotion is identified by its lexical indication in the reporting clause (said angrily) accompanied by the direct speech which is assumed to verbalize the emotion.
Aleš Klégr, Pavlína Šaldová
doaj   +1 more source

Implementing log-add algorithm in hardware [PDF]

open access: yes, 2003
A hardware implementation of the log-add algorithm, being a simple method of computing ln(A + B) given ln(A) and ln(B), as used in speech recognition, is presented.
Melnikoff, Stephen Jonathan   +1 more
core  

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