Results 71 to 80 of about 10,147,983 (339)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Frequency margin evaluation for hybrid alternating-current/direct-current grids under high renewable penetration: a scalable online framework

International Journal of Electrical Power & Energy Systems
With the rapid expansion of renewable energy and the development of cross-regional hybrid alternating-current/direct-current power grids, frequency stability is facing new challenges characterized by low inertia and multiple disturbances.
Lulu Zhang, Ying Lv, Zhihong Yu, Baocai Wang, Qiyong Liu, Zhaoyuan Wu, Huadong Sun   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Transient Synchronous Stability Evaluation of Heterogeneous Power Grids With Grid‐Following and Grid‐Forming Converters by Manifold Theory

IET Renewable Power Generation
The energy function method developed from Lyapunov theory is a typical direct method to evaluate the transient synchronous stability of traditional power grids.
Saizhao Yang, Rui Ma, Yitong Li, Jinyu Wen   +3 more
doaj   +1 more source

Enhancing trustworthiness in deep learning-based transient stability assessment: A multi-head attention model with dual-level interpretability

International Journal of Electrical Power & Energy Systems
Applying deep learning (DL) methods to transient stability assessment (TSA) facilitates the rapid establishment of a direct connection between operational features and transient states.
Zhewen Niu, Yuxiang Wu, Songyan Lan, Chaohui Wu, Xiaoqing Han, Jie Chen   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Out-of-Step Protection for a Synchronous Generator via Energy Function-Based Stability Assessment Using a Single Local Speed Measurement

IEEE Access
This study proposes a scheme for determining the loss of synchronism in synchronous generators based on the direct method, utilizing a single local speed measurement within a generator system.
Jongju Kim
doaj   +1 more source

Basic directions economic assessment of stability state enterprise «Dnieper railway»

Problemi ekonomìki transportu, 2015
The purpose. The work deals with the approaches to assessing the economic sustainability of railway transport, search for ways to develop methodological approaches, introduction of innovative technical tools and methods to assess the economic condition. Methods. To ensure an objective assessment of the economic condition of railway transport in invited
openaire   +2 more sources