Results 81 to 90 of about 358,699 (263)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Review on Anaerobic Digestate as a Biofertilizer: Characteristics, Production, and Environmental Impacts from a Life Cycle Assessment Perspective

Applied Sciences
Digestate valorization is essential for sustainable waste management and circular economy strategies, yet large-scale adoption faces technical, economic, and environmental challenges.
Carmen Martín-Sanz-Garrido, Marta Revuelta-Aramburu, Ana María Santos-Montes, Carlos Morales-Polo   +3 more
doaj   +1 more source

Impact of different beverages on color and structural characteristics of aesthetic composite resins [PDF]

Journal of Dental Materials and Techniques
Objective: This study evaluated the color stability and surface roughness of two composite resins, Gradia Direct and Omnichroma, after immersion in various solutions.Methods: In this in-vitro study, 80 composite resin samples were divided into two groups
Marzieh Rohaninasab, Zainab Qeas Abul-Hadi Al-Haideri, Behnaz Behniafar   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

THE CONCEPT OF RISK MANAGEMENT: AN INTEGRATED ANALYSIS BASED ON THE CRITERIA OF THE FINANCIAL CONDITION OF ENTERPRISES

Фінансово-кредитна діяльність: проблеми теорії та практики
The article is a theoretical and methodological study of risks as an important concept of enterprise management, highlighting the methodology of comprehensive risk analysis based on the criteria of the enterprise's financial condition.
Svitlana Zhukevych , Viktoria Rozheljuk , Тetiana Portovaras, Natalіa Zhuk, Pavlo Denchuk   +4 more
doaj   +1 more source

Macroeconomic Stability and Its Impact on the Economic Growth of the Country [PDF]

Montenegrin Journal of Economics, 2018
The main purpose of this research is to study the role and impact force of macroeconomic stability on economic growth in the period from 2000 to 2016, using the modified Cobb–Douglas production function.
Tatiana Vasylieva, Sergij Lyeonov, Oleksii Lyulyov, Kostiantyn Kyrychenko   +3 more
doaj  

ASSESSMENT OF THE FINANCIAL STABILITY OF AN ENTERPRISE AND THE DIRECTIONS OF ITS PROVISION [PDF]

Vìsnik Lʹvìvsʹkogo nacìonalʹnogo agrarnogo unìversitetu. Ekonomìka APK, 2021
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source