Results 61 to 70 of about 14,176 (292)

Representing Variant Calling Format as Directed Acyclic Graphs to Enable the Use of Cloud Computing for Efficient and Cost Effective Genome Analysis

, 2017
Ever since the completion of the Human Genome Project in 2003, the human genome has been represented as a linear sequence of 3.2 billion base pairs and is referred to as the "Reference Genome".
Rizos Sakellariou, Aizad, Sanna, Anjum, Ashiq, Sakellariou, Rizos, Sanna Aizad, Ashiq Anjum   +5 more
core   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

Minimal sufficient causation and directed acyclic graphs

, 2019
Notions of minimal sufficient causation are incorporated within the directed acyclic graph causal framework. Doing so allows for the graphical representation of sufficient causes and minimal sufficient causes on causal directed acyclic graphs while ...
VanderWeele, Tyler J., Robins, James M.
core   +1 more source

The Interoperability Challenge in DFT Workflows Across Implementations

Advanced Intelligent Discovery, EarlyView.
Interoperability and cross‐validation remain major challenges in the computational materials science. In this work, we introduce a common input/output standard that enables internal translation across multiple workflow managers—AiiDA, PerQueue, Pipeline Pilot, and SimStack—while producing results in a unified schema.
Simon K. Steensen, Tushar Singh Thakur, Manuel Dillenz, Johan M. Carlsson, Celso R. C. Rêgo, Eibar Flores, Hamidreza Hajiyani, Felix Hanke, Juan María García Lastra, Wolfgang Wenzel, Nicola Marzari, Tejs Vegge, Giovanni Pizzi, Ivano E. Castelli   +13 more
wiley   +1 more source

Bayesian Network Learning with the PC Algorithm: An Improved and Correct Variation

Applied Artificial Intelligence, 2019
PC is a prototypical constraint-based algorithm for learning Bayesian networks, a special case of directed acyclic graphs. An existing variant of it, in the R package pcalg, was developed to make the skeleton phase order independent.
Michail Tsagris
doaj   +1 more source

Psychological distress and mother-child relationship: influence of life context on a population sample (BRISA) through the use of directed acyclic graphs (DAG) [PDF]

Brazilian Journal of Medical and Biological Research
This study aimed to investigate the association between maternal psychological distress and impairment in mother-child relationship in a sample from a Northeast capital city in Brazil with a low Human Development Index, using directed acyclic graphs (DAG)
M.C.V. Cavalcante, Z.C. Lamy, A.K.T.C. França, M.U.L. Pereira, A.A. Ferraro, M.A. Barbieri, F. Lamy-Filho   +6 more
doaj   +2 more sources

Adjustment for collider bias in the hospitalized Covid-19 setting

Global Epidemiology, 2023
Background: Causal directed acyclic graphs (cDAGs) are frequently used to identify confounding and collider bias. We demonstrate how to use causal directed acyclic graphs to adjust for collider bias in the hospitalized Covid-19 setting.
Moslem Taheri Soodejani, Seyyed Mohammad Tabatabaei, Mohammad Hassan Lotfi, Maryam Nazemipour, Mohammad Ali Mansournia   +4 more
doaj   +1 more source

Uncovering renewable energy policy impact channels on land values, the local farm structure, and farmland heterogeneity

American Journal of Agricultural Economics, EarlyView.
Abstract Germany's Renewable Energy Sources Act (REA), enacted in 2000 and subsequently amended, subsidized national renewable energy production with fixed feed‐in tariffs for renewable energy sources (RE) from wind, solar, and biogas. Empirical studies suggest that the policy was creating windfall effects for landowners and attribute farmland use ...
Lars Isenhardt, Stefan Seifert, Saskia Wolff, Tobia Lakes, Marten Graubner, Axel Werwatz, Silke Hüttel   +6 more
wiley   +1 more source

Broadcasting on Random Directed Acyclic Graphs

IEEE Transactions on Information Theory, 2020
33 pages, double column format.
Anuran Makur, Elchanan Mossel, Yury Polyanskiy   +2 more
openaire   +3 more sources