Results 71 to 80 of about 694,148 (329)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Multi-faceted monitoring of powder flow rate variability in directed energy deposition

Additive Manufacturing Letters, 2022
Powder flow rate is a key parameter in Directed Energy Deposition (DED) processes. During a typical build, if powder flow rate is reduced for just 1 second, 30 mm of melt track is affected.
Felicity S.H.B. Freeman, B Thomas, L Chechik, Iain Todd   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Excellent superelasticity in a Co-Ni-Ga high-temperature shape memory alloy processed by directed energy deposition

Materials Research Letters, 2020
A Co-Ni-Ga high-temperature shape memory alloy has been additively manufactured by directed energy deposition. Due to the highly anisotropic microstructure, i.e.
C. Lauhoff, N. Sommer, M. Vollmer, G. Mienert, P. Krooß, S. Böhm, T. Niendorf   +6 more
doaj   +1 more source

Inconel 718 two ways: Powder bed fusion vs. directed energy deposition

Additive Manufacturing Letters, 2023
Additive manufacturing (AM) research has grown massively in the last few decades, with applications ranging from the medical sector to automotive. AM of nickel superalloys is of great interest for the aerospace sector due to their mechanical performance ...
Lova Chechik, Iain Todd
doaj   +1 more source

An Anisotropic Ballistic Deposition Model with Links to the Ulam Problem and the Tracy-Widom Distribution

, 2003
We compute exactly the asymptotic distribution of scaled height in a (1+1)--dimensional anisotropic ballistic deposition model by mapping it to the Ulam problem of finding the longest nondecreasing subsequence in a random sequence of integers.
A.M. Vershik, C.A. Tracy, C.A. Tracy, D. Aldous, D. Dhar, D. Kim, F.C. Frank, J. Baik, J. Baik, J. Gravner, J. Kertész, J. Krug, J. Krug, J.M. Kim, K. Johansson, L.-H. Gwa, M. Kardar, M. Prähofer, M. Prähofer, M.J. Vold, P. Meakin, R. Rajesh, Satya N. Majumdar, Sergei Nechaev, T. Halpin-Healy   +24 more
core   +1 more source

Printability disparities in heterogeneous material combinations via laser directed energy deposition: a comparative study

International Journal of Extreme Manufacturing
Additive manufacturing provides achievability for the fabrication of bimetallic and multi-material structures; however, the material compatibility and bondability directly affect the parts’ formability and final quality. It is essential to understand the
Jinsheng Ning, Lida Zhu, Shuhao Wang, Zhichao Yang, Peihua Xu, Pengsheng Xue, Hao Lu, Miao Yu, Yunha Zhao, Jiachen Li, S. Bose, Amit Bandyopadhyay   +11 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cost Modelling for Powder Bed Fusion and Directed Energy Deposition Additive Manufacturing

Journal of Manufacturing and Materials Processing
Additive manufacturing (AM) is increasingly used for fabricating parts directly from digital models, usually by depositing and bonding successive layers of various materials such as polymers, metals, ceramics, and composites.
Navneet Khanna, Harsh Salvi, Büşra Karaş, Ishrat Fairoz, A. Shokrani   +4 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source