Results 121 to 130 of about 11,830,288 (332)

Engineering the functional fitness of transglycosidases and glycosynthases by directed evolution [PDF]

, 2013
The artificial implementation of the Darwinian theory of evolution to create new variants of functional proteins, a process referred to as directed evolution, has acquired many applications in biochemical engineering.
Bulimo, WD, Osanjo, GO, Mulaa, FJ
core   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source

Directed evolution of TEAS.

, 2014
(a) Procedure for the directed evolution of TEAS for higher cellular activity. (b) The carotenoid production level of E. coli cells harboring TEAS variants and pAC-MN-idi. (c) E. coli production of 5EA by TEAS variants.
Maiko Furubayashi (544674), Akira Fujii (544678), Jun Kajiwara (544676), Miki Iwasaki (544677), Ling Li (38566), Mayu Ikezumi (544675), Daisuke Umeno (544680), Kyoichi Saito (544679)   +7 more
core   +1 more source

A directed mutation operator for real coded genetic algorithms [PDF]

, 2010
Copyright @ Springer-Verlag Berlin Heidelberg 2010.Developing directed mutation methods has been an interesting research topic to improve the performance of genetic algorithms (GAs) for function optimization. This paper introduces a directed mutation (DM)
Yang, S, Li, Changhe, Shengxiang Yang, Kojero, Imtiaz, Imtiaz Korejo, Yang, Shengxiang, Changhe Li, Li, C, Korejo, I   +8 more
core   +1 more source

Feeding, Fear, and Acceptance: Caregivers’ Experiences of Nutritional Support During Childhood Cancer Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose To explore caregivers' experiences and perceptions of the nutritional challenges faced by children and adolescents undergoing cancer treatment, including oral intake and the use of nutritional support. Methods This was a qualitative study based on focus groups with parents and caregivers at a Brazilian pediatric oncology hospital ...
Danyelle Apparecida Balsamão Marques, Mariana dos Santos Murra, Welinton Hirai, Ana Laura Balduino do Nascimento, Karla Emilia de Sá Rodrigues, Wilson Elias de Oliveira Junior   +5 more
wiley   +1 more source

COMPUTER-AIDED PROTEIN DIRECTED EVOLUTION: A REVIEW OF WEB SERVERS, DATABASES AND OTHER COMPUTATIONAL TOOLS FOR PROTEIN ENGINEERING

Computational and Structural Biotechnology Journal, 2012
The combination of computational and directed evolution methods has proven a winning strategy for protein engineering. We refer to this approach as computer-aided protein directed evolution (CAPDE) and the review summarizes the recent developments in ...
Rajni Verma, Ulrich Schwaneberg, Danilo Roccatano   +2 more
doaj   +3 more sources

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters

Nature Chemical Biology, 2018
We developed a new way to engineer complex proteins toward multidimensional specifications using a simple, yet scalable, directed evolution strategy. By robotically picking mammalian cells that were identified, under a microscope, as expressing proteins ...
Kiryl D Piatkevich, Erica E. Jung, Christoph Straub, Chang-Yang Linghu, Demian Park, Ho-Jun Suk, D. Hochbaum, Daniel R. Goodwin, E. Pnevmatikakis, N. Pak, T. Kawashima, Chao-Tsung Yang, Jeffrey L. Rhoades, O. Shemesh, Shoh M. Asano, Young-Gyu Yoon, Limor Freifeld, J. L. Saulnier, Clemens Riegler, F. Engert, T. Hughes, M. Drobizhev, B. Szabó, M. Ahrens, S. Flavell, B. Sabatini, E. Boyden   +26 more
semanticscholar   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

When directed evolution met ancestral enzyme resurrection

, 2017
The directed evolution of ancestral ‐resurrected‐ enzymes can give a new twist in protein engineering approaches towards more versatile and robust biocatalysts.Peer ...
Miguel Alcalde, Alcalde Galeote, Miguel
core   +1 more source