Results 271 to 280 of about 11,830,288 (332)

Harnessing a germ‑free mouse gut bioreactor for directed evolution of probiotics to combat non-alcoholic fatty liver disease. [PDF]

Nat Commun
Han Z, Sun Z, Liu X, Zhen D, Guo Q, Zheng L, Jiang S, Zhang Z, Shen S, Zhang J.   +9 more
europepmc   +1 more source

How far can you go? Extrapolating values of catalytic activity from known protein landscapes in natural and directed evolution.

Chem Soc Rev
Kell DB, Roberts I.
europepmc   +1 more source

Engineered AAV Capsids with Enhanced Extracellular Vesicle Loading via Rational Design and Directed Evolution

Vorobieva I, Luchner M, Friedrichsen H, Makkar R, Chester S, Haughton E, Conceiao M, Steel H, Sanders SJ, Wood MP, Gupta D.   +10 more
europepmc   +1 more source

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The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes

Angewandte Chemie - International Edition, 2020
Directed evolution of stereo-, regio- and chemoselective enzymes provides a means to generate biocatalysts for synthetically interesting transformations. In order for this protein engineering technique to be efficient, fast and reliable, and of relevance
Aitao Li, Manfred T. Reetz, Ge Qu
exaly   +2 more sources

Directed evolution

Nature Biotechnology
Aaron M. Leconte, C. Colee
semanticscholar   +6 more sources

Complete Depolymerization of PET Waste by an Evolved PET Hydrolase from Directed Evolution.

Angewandte Chemie, 2023
PETase displays great potential in PET depolymerization. Directed evolution has been limited to engineer PETase due to the lack of high-throughput screening assay.
Li-Xia Shi, Ping Liu, Zi-yang Tan, Wei Zhao, Jun-Fei Gao, Qun Gu, Hong-Wu Ma, Haifeng Liu, Lei-Lei Zhu   +8 more
semanticscholar   +1 more source

Directed Evolution: Methodologies and Applications.

Chemical Reviews, 2021
Directed evolution aims to expedite the natural evolution process of biological molecules and systems in a test tube through iterative rounds of gene diversifications and library screening/selection.
Yajie Wang, P. Xue, Mingfeng Cao, Tian-Hao Yu, S. Lane, Hui-Min Zhao   +5 more
semanticscholar   +1 more source

Directed Evolution and Biocatalysis [PDF]

Angewandte Chemie - International Edition, 2001
This review describes the current state of biocatalysis in the chemical industry. Although we recognize the advantages of chemical approaches, we suggest that the use of biological catalysis is about to expand dramatically because of the recent developments in the artificial evolution of genes that code for enzymes. For the first time it is possible to
Gjalt Huisman
exaly   +3 more sources

Directed enzyme evolution

Current Opinion in Biotechnology, 2001
Laboratory evolutionists continue to generate better enzymes for industrial and research applications. Exciting developments include new biocatalysts for enantioselective carbon-carbon bond formation and fatty acid production in plants. Creative contributions to the repertoire of evolutionary methods will ensure further growth in applications and ...
Farinas, Edgardo T., Bulter, Thomas, Arnold, Frances H.   +2 more
openaire   +3 more sources