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Emerging Topics in Life Sciences, 2020 There are near-to-infinite combinations of possibilities for evolution to happen within nature, making it yet impossible to predict how it occurs. However, science is now able to understand the mechanisms underpinning the evolution of biological systems and can use this knowledge to experimentally mimic nature.
Tamaki, Fabio K.
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The Evolution of Advance Directives
JAMA, 2011THERE ARE 2 WIDELY KNOWN PROBLEMS WITH END-OFlife care in the United States. First, care often does not reflect patients’ values and preferences. Second, end-of-life care constitutes a disproportionate amount of health care expenditures. There is a need to improve the value of health care spending because of changing economic and political climates and
Douglas B, White, Robert M, Arnold
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Directed Evolution of Aldolases
2004Publisher Summary This chapter describes the directed evolution of aldolases. The detailed protocols for generating aldolases with new catalytic properties are presented. The gene encoding aldolase can be amplified using the standard polymerase chain reaction (PCR) from a genomic DNA preparation using the Qiagen kit and primers flanking the gene with
Dirk, Franke +2 more
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Origins of life and evolution of the biosphere, 1999
We propose the existence of a relationship of stereochemical complementarity between gene sequences that code for interacting components: nucleic acid-nucleic acid, protein-protein and protein-nucleic acid. Such a relationship would impose evolutionary constraints on the DNA sequences themselves, thus retaining these sequences and governing the ...
L F, Harris +2 more
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We propose the existence of a relationship of stereochemical complementarity between gene sequences that code for interacting components: nucleic acid-nucleic acid, protein-protein and protein-nucleic acid. Such a relationship would impose evolutionary constraints on the DNA sequences themselves, thus retaining these sequences and governing the ...
L F, Harris +2 more
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Current Opinion in Biotechnology, 2001
Laboratory evolutionists continue to generate better enzymes for industrial and research applications. Exciting developments include new biocatalysts for enantioselective carbon-carbon bond formation and fatty acid production in plants. Creative contributions to the repertoire of evolutionary methods will ensure further growth in applications and ...
Farinas, Edgardo T. +2 more
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Laboratory evolutionists continue to generate better enzymes for industrial and research applications. Exciting developments include new biocatalysts for enantioselective carbon-carbon bond formation and fatty acid production in plants. Creative contributions to the repertoire of evolutionary methods will ensure further growth in applications and ...
Farinas, Edgardo T. +2 more
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Angewandte Chemie International Edition, 1998
On the way to a combinatorial biotechnology? The directed evolution of enzymes promises a rapid access to effective biocatalysts. New molecular biology techniques for random mutagenesis in combination with high-throughput screening might revolutionize the creation of enzymes with new and improved properties.
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On the way to a combinatorial biotechnology? The directed evolution of enzymes promises a rapid access to effective biocatalysts. New molecular biology techniques for random mutagenesis in combination with high-throughput screening might revolutionize the creation of enzymes with new and improved properties.
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Directed evolution: selecting today's biocatalysts
Biomolecular Engineering, 2005Directed evolution has become a full-grown tool in molecular biology nowadays. The methods that are involved in creating a mutant library are extensive and can be divided into several categories according to their basic ideas. Furthermore, both screening and selection can be used to target the enzyme towards the desired direction.
Otten, Linda, Quax, Wim
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Directed Evolution of Adenoviruses
2016The ability to evolve viruses in cell culture in the face of selective pressure is an invaluable method to elucidate the molecular mechanisms of synthetic or natural antivirals, expand tropism, or alter virulence. Recently, mutations to the human adenovirus polymerase that reduce replicative fidelity were described, and we have incorporated one of ...
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Directed evolution of biocatalytic processes
Biomolecular Engineering, 2005The benefits of applying biocatalysts to organic synthesis, such as their high chemo-, regio-, and enantio-specificity and selectivity, must be seriously considered, especially where chemical routes are unavailable, complex or prohibitively expensive.
Edward G, Hibbert +6 more
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Protein Design by Directed Evolution
Annual Review of Biophysics, 2008While nature evolved polypeptides over billions of years, protein design by evolutionary mimicry is progressing at a far more rapid pace. The mutation, selection, and amplification steps of the evolutionary cycle may be imitated in the laboratory using existing proteins, or molecules created de novo from random sequence space, as starting templates ...
Jäckel C, Kast P, Hilvert D
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