Results 261 to 270 of about 11,830,288 (332)

Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling. [PDF]

ACS Cent Sci
Ogorek AN, Pani S, Mertick-Sykes EJ, Momirov J, Lao Y, Mejia FB, Chan RST, Huang X, Dickinson BC, Martell JD.   +9 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Directed evolution of chlorotoxin enhances MMP-2 recognition and improves CAR-T-cell activity in glioblastoma models <i>in vitro</i>. [PDF]

Front Bioeng Biotechnol
Hajdara A, Szöőr Á, Murányi J, Brunyánszki A, Rácz GZ, Cioca D, Gordos A, Bata N, Nagy N, Fedorcsák I, Sipos L, Kisgyörgy M, Megyeri M, Péterfi Z, Farkas S, Hornyák P.   +15 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Enhancing O-linking oligosaccharyltransferase functionality through directed evolution. [PDF]

J Biol Chem
Edwards RL, McAllister KN, McGuffey JC, Knoot CJ, Hooppaw AJ, Mackel JJ, Zhou B, Robinson LS, Scott NE, Harding CM.   +9 more
europepmc   +1 more source

Directed evolution of a plant Rubisco chaperone with altered client recognition. [PDF]

Proc Natl Acad Sci U S A
Li S, Lee B, Lao Y, Lertwiriyapiti S, Huang X, Wang T.   +5 more
europepmc   +1 more source

Directed evolution expands CRISPR-Cas12a genome-editing capacity. [PDF]

Nucleic Acids Res
Ma E, Chen K, Shi H, Wasko KM, Esain-Garcia I, Trinidad MI, Zhou K, Ye J, Doudna JA.   +8 more
europepmc   +1 more source

A Nonviral Neo-Nucleocapsid for Cell-Specific RNA Delivery Developed by Pseudo-Cyclic Peptide Grafting and Directed Evolution. [PDF]

Angew Chem Int Ed Engl
Kanayama D, Terasaka N, Kato K, Okazaki S, Suga H.   +4 more
europepmc   +1 more source