Results 41 to 50 of about 1,263,669 (205)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
The storage capacity of a directed graph and nodewise autonomous, ubiquitous learning
Frontiers in Computational Neuroscience, 2023 The brain, an exceedingly intricate information processing system, poses a constant challenge to memory research, particularly in comprehending how it encodes, stores, and retrieves information.
Hui Wei, Fushun Li
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
The Burning Number of Directed Graphs: Bounds and Computational Complexity [PDF]
, 2020 The burning number of a graph was recently introduced by Bonato et al. Although they mention that the burning number generalizes naturally to directed graphs, no further research on this has been done. Here, we introduce graph burning for directed graphs,
Janssen, Remie, Janssen, R. (author)
core +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Inducibility of directed paths [PDF]
, 2020 A long standing open problem in extremal graph theory is to describe all graphs that maximize the number of induced copies of a path on four vertices.
Choi, Ilkyoo +2 more
core
From path graphs to directed path graphs [PDF]
, 2021 We present a linear time algorithm to greedily orient the edges of a path graph model to obtain a directed path graph model (when possible). Moreover we extend this algorithm to find an odd sun when the method fails.
Lévêque, Benjamin +3 more
core
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Understanding normal and restricted normal products in soft directed graphs
Journal of Nigerian Society of Physical SciencesThis paper extends the framework of soft set theory to directed graphs by introducing and analyzing the concepts of the normal product and restricted normal product of soft directed graphs.
Jinta Jose +3 more
doaj +1 more source