Results 51 to 60 of about 1,263,669 (205)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
On incidence algebras and directed graphs
International Journal of Mathematics and Mathematical Sciences, 2002 The incidence algebra I(X,ℝ) of a locally finite poset (X,≤) has been defined and studied by Spiegel and O'Donnell (1997). A poset (V,≤) has a directed graph (Gv,≤) representing it.
Ancykutty Joseph
doaj +1 more source
Extrema property of the k-ranking of directed paths and cycles
AKCE International Journal of Graphs and Combinatorics, 2016 A k-ranking of a directed graph G is a labeling of the vertex set of G with k positive integers such that every directed path connecting two vertices with the same label includes a vertex with a larger label in between.
Breeanne Baker Swart +3 more
doaj +1 more source
Negation Switching Equivalence in Signed Graphs [PDF]
, 2010 Unless mentioned or defined otherwise, for all terminology and notion in graph theory the reader is refer to [8].
Reddy, Siva Kota
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Limiting behaviour of random spatial graphs and asymptotically homogeneous RWRE [PDF]
, 2005 We consider several random spatial graphs of the nearest-neighbour type, including the k- nearest neighbours graph, the on-line nearest-neighbour graph, and the minimal directed spanning tree.
Wade, Andrew R +2 more
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Fixation times on directed graphs.
PLoS Computational BiologyComputing the rate of evolution in spatially structured populations is difficult. A key quantity is the fixation time of a single mutant with relative reproduction rate r which invades a population of residents. We say that the fixation time is "fast" if
David A Brewster +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source