Results 111 to 120 of about 495,896 (276)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Directed Evolution with Fast and Efficient Selection Technologies

CHIMIA, 2001
Directed molecular evolution has proven to be a very powerful concept for the generation of proteins with improved properties, such as increased activity, binding affinity, folding efficiency or enhanced chemical and/or thermodynamic stability ...
Ekkehard Mössner, Andreas Plückthun
doaj  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Coherent spin relaxation in molecular magnets

, 2008
Numerical modelling of coherent spin relaxation in nanomagnets, formed by magnetic molecules of high spins, is accomplished. Such a coherent spin dynamics can be realized in the presence of a resonant electric circuit coupled to the magnet.
A. Abraham, A. E. Siegman, A. V. Andreev, C. Paulsen, L. Mandel, N. A. Bazhanov, N. A. Bazhanov, N. P. Fokina, N. P. Fokina, O. Kahn, O. V. Nazarova, P. V. Kharebov, T. M. Shavishvili, T. S. Belozerova, V. I. Yukalov, V. I. Yukalov, V. I. Yukalov, V. I. Yukalov, V. I. Yukalov, V. I. Yukalov, V. I. Yukalov, V. K. Henner, V. M. Fain, W. Wersndorfer, Y. F. Kiselev   +24 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Squid-Inspired Tandem Repeat Proteins: Functional Fibers and Films

Frontiers in Chemistry, 2019
Production of repetitive polypeptides that comprise one or more tandem copies of a single unit with distinct amorphous and ordered regions have been an interest for the last couple of decades.
Abdon Pena-Francesch, Abdon Pena-Francesch, Melik C. Demirel, Melik C. Demirel   +3 more
doaj   +1 more source

Consequences of a covariant Description of Heavy Ion Reactions at intermediate Energies

, 1995
Heavy ion collisions at intermediate energies are studied by using a new RQMD code, which is a covariant generalization of the QMD approach. We show that this new implementation is able to produce the same results in the nonrelativistic limit (i.e. 50MeV/
A. Bonasera, A. Komar, A. Komar, A. Komar, A. P. Balachandran, Amand Faessler, C. Fuchs, C. Grégoire, C. M. Ko, D. Dominici, D. Dominici, D. Dominici, D. G. Currie, E. C. G. Sudarshan, E. Lehmann, E. Lehmann, F. Rohrlich, G. Batko, G. F. Bertsch, G. F. Bertsch, H. Kruse, H. Sorge, I. T. Todorov, J. Aichelin, J. Aichelin, J. Cugnon, J. Samuel, J. Samuel, P. A. M. Dirac, R. Schmidt, Rajeev K. Puri, S. W. Huang, T. Kodama, T. Maruyama, T. Maruyama, W. Bauer, W. Cassing   +36 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science
Aptamers are highly selective nucleic acid ligands that overcome many challenges of antibodies, including structural instability and high production costs.
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
doaj   +1 more source

On the simulation of enzymatic digest patterns: the fragmentation of oligomeric and polymeric galacturonides by endo-polygalacturonase II

, 2006
A simulation methodology for predicting the time-course of enzymatic digestions is described. The model is based solely on the enzyme's subsite architecture and concomitant binding energies.
Allen, André-Leroux, Armand, Benen, Bonnin, Bussink, Cameron, Cameron, Cameron, Daas, Daas, Daas, Daas, Davies, Dea, DeVries, Goodall, Goubet, Grant Reid, Gyöngyi, Henrissat, Henrissat, Henrissat, Jonathan J. Hunt, King, Körner, Limberg, Limberg, Martin A.K. Williams, Matsumoto, McCleary, Nitta, Ostgaard, Pagès, Pagès, Randall Cameron, Rexová-Benková, Ridley, Ström, Suganuma, Thoma, Thoma, Van Santen, Williams, Williams, Williams   +45 more
core   +1 more source