Results 91 to 100 of about 169,578 (300)

Different Approaches For Protein Engineering In Industrial Biotechnology

, 2011
Protein engineering is the novel field which has wide applications from pharmaceutics, industry, commercial, laundry and research. It may apply rational design or non rational design or both.
Muhammad Waheed Akhtar, Israr Khan
core  

How Proteins Adapt: Lessons from Directed Evolution [PDF]

, 2009
Applying artificial selection to create new proteins has allowed us to explore fundamental processes of molecular evolution. These "'directed evolution" experiments have shown that proteins can readily adapt to new functions or environments via simple ...
Arnold, F. H.
core  

Emerging Frontiers in the Study of Molecular Evolution

, 2020
A collection of the editors of Journal of Molecular Evolution have gotten together to pose a set of key challenges and future directions for the field of molecular evolution. Topics include challenges and new directions in prebiotic chemistry and the RNA
Kaçar, Betül, Storfer, Andrew, Hey, Jody, Meyer, Michelle, Posada, David, Chang, Belinda, Geiler-Samerotte, Kerry, Murphy, William, Goldman, Aaron D., Liberles, David A.   +9 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Directed evolution and structural analysis of an OB-fold domain towards a specifc binding reagent

, 2011
Interactions between proteins are a central concept in biology, and understanding and manipulation of these interactions is key to advancing biological science.
Steemson, John Durand
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

{Co4O4} Cubanes in a conducting polymer matrix as bio-inspired molecular oxygen evolution catalysts

Nature Communications
Exploration of efficient molecular water oxidation catalysts for long-term application remains a key challenge for the conversion of renewable energy sources into fuels.
Shangkun Li, Zeyi Zhang, Walker R. Marks, Xinan Huang, Hang Chen, Dragos C. Stoian, Rolf Erni, Carlos A. Triana, Greta R. Patzke   +8 more
doaj   +1 more source

Directed evolution of ancestral and modern enzymes [PDF]

, 2021
Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de lectura: 18-10-2019Esta tesis tiene embargado el acceso al texto completo hasta el 18-04-2021Ancestral sequence ...
Gómez Fernández, Bernardo José
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Directed Evolution with Fast and Efficient Selection Technologies

CHIMIA, 2001
Directed molecular evolution has proven to be a very powerful concept for the generation of proteins with improved properties, such as increased activity, binding affinity, folding efficiency or enhanced chemical and/or thermodynamic stability ...
Ekkehard Mössner, Andreas Plückthun
doaj