Results 71 to 80 of about 493,855 (292)

Probabilistic Graphical Model Representation in Phylogenetics [PDF]

, 2013
Recent years have seen a rapid expansion of the model space explored in statistical phylogenetics, emphasizing the need for new approaches to statistical model representation and software development.
Boussau, Bastien, Heath, Tracy A., Huelsenbeck, John P., Höhna, Sebastian, Landis, Michael J., Ronquist, Fredrik   +5 more
core   +2 more sources

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

The asexual genome of Drosophila

, 2017
The rate of recombination affects the mode of molecular evolution. In high-recombining sequence, the targets of selection are individual genetic loci; under low recombination, selection collectively acts on large, genetically linked genomic segments ...
Lässig, Michael, Mustonen, Ville, Schiffels, Stephan   +2 more
core   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Protein engineering of conger eel galectins by tracing of molecular evolution using probable ancestral mutants

BMC Evolutionary Biology, 2010
Background Conger eel galectins, congerin I (ConI) and congerin II (ConII), show the different molecular characteristics resulting from accelerating evolution. We recently reconstructed a probable ancestral form of congerins, Con-anc.
Shirai Tsuyoshi, Muramoto Koji, Kitagawa Atsushi, Yonemaru Shintarou, Konno Ayumu, Ogawa Tomohisa   +5 more
doaj   +1 more source

Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones [PDF]

, 2005
LuxR-type transcriptional regulators play key roles in quorum-sensing systems that employ acyl-homoserine lactones (acyl-HSLs) as signal molecules.
Arnold, Frances H., Collins, Cynthia H., Leadbetter, Jared R.   +2 more
core  

Origin of symbol-using systems: speech, but not sign, without the semantic urge [PDF]

, 2014
Natural language—spoken and signed—is a multichannel phenomenon, involving facial and body expression, and voice and visual intonation that is often used in the service of a social urge to communicate meaning.
Alberts B, Baldwin JM, Darwin C, Darwin C, Deacon TW, Donald M, Fauconnier G, Gross CG, Hauser M, Jablonski NG, Jackendoff R, Judson HF, Kendon A, King BJ, Klima ES, Knight C, Langacker R, Martin I. Sereno, Merker B, Miller SL, Mithen S, Rubens AB, Sereno MI, Sereno MI, Sereno ML, Wills C, Woese CR, Yip M   +27 more
core   +2 more sources

Expanded molecular diversity generation during directed evolution by trinucleotide exchange (TriNEx) [PDF]

Nucleic Acids Research, 2008
Trinucleotide exchange (TriNEx) is a method for generating novel molecular diversity during directed evolution by random substitution of one contiguous trinucleotide sequence for another. Single trinucleotide sequences were deleted at random positions in a target gene using the engineered transposon MuDel that were subsequently replaced with a ...
Baldwin, Amy Joy, Busse, K., Simm, A. M., Jones, Darran Dafydd   +3 more
openaire   +3 more sources

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

A C35 Carotenoid Biosynthetic Pathway [PDF]

, 2003
Upon coexpression with Erwinia geranylgeranyldiphosphate (GGDP) synthase in Escherichia coli, C30 carotenoid synthase CrtM from Staphylococcus aureus produces novel carotenoids with the asymmetrical C35 backbone.
Arnold, Frances H., Umeno, Daisuke
core