Results 91 to 100 of about 1,830,098 (281)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Equilibrium Directed Search with Multiple Applications [PDF]
TBEquilibrium Directed ...
James Albrecht, Pieter Gautier
core
Automatic and Accurate Acquisition of Stem-Related Phenotypes of Mature Soybean Based on Deep Learning and Directed Search Algorithms. [PDF]
Front Plant Sci, 2022 Guo Y +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Directed Search in the Housing Market [PDF]
In this paper, we present a directed search model of the housing market. The pricing mechanism we analyze reflects the way houses are bought and sold in the United States. Our model is consistent with the observation that houses are sometimes sold above,
Albrecht, James +2 more
core
A Monetary Theory with Non-Degenerate Distributions [PDF]
Dispersion of money balances among individuals is the basis for a range of policies but it has been abstracted from in monetary theory for tractability reasons.
Guido Menzio, Hongfei Sun, Shouyong Shi
core +6 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Equilibrium Directed Search with Multiple Application [PDF]
We analyze a model of directed search in which unemployed job seekers observe all posted wages. We allow for the possibility of multiple applications by workers and ex post competition among vacancies.
James Albrecht, Pieter Gautier, & Susan Vroman
core
The Local Galactic Transient Survey Applied to an Optical Search for Directed Intelligence
The Astrophysical JournalWe discuss our transient search for directed energy systems in local galaxies, with calculations indicating the ability of modest searches to detect optical Search for Extraterrestrial Intelligence sources in the closest galaxies. Our analysis follows P.
Alex Thomas +28 more
doaj +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source