Results 101 to 110 of about 679,253 (302)

Ligand-enabled Ni-catalysed dicarbofunctionalisation of alkenes with diverse native functional groups

open access: yesNature Communications
The transition metal-catalysed dicarbofunctionalisation of unactivated alkenes normally requires exogenous strong coordinated directing groups, thus reducing the overall reaction efficiency.
Dao-Ming Wang   +7 more
doaj   +1 more source

KOMPETENSI MANAJERIAL KONSELOR PADA LAYANAN KONSELING KELOMPOK

open access: yesAl-Tanzim: Jurnal Manajemen Pendidikan Islam, 2019
The purpose of this study was to determine the managerial ability of the counselor in implementing group counseling at school. The research method used is qualitative, data analysis used is drawing conclusions based on Lawrence's theory.
Dody Riswanto
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Pd(II)-catalysed meta-C–H functionalizations of benzoic acid derivatives

open access: yesNature Communications, 2016
While directed ortho-metalation is a well-established protocol, meta-functionalisation of aromatic groups is more challenging. Here, the authors report a directed meta-C-H functionalisation of benzoic acid derivatives, using a nitrile-based sulfonamide ...
Shangda Li   +4 more
doaj   +1 more source

Spartan Daily, May 16, 1947 [PDF]

open access: yes, 1947
Volume 35, Issue 137https://scholarworks.sjsu.edu/spartandaily/9002/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Consumer Direction of Personal Assistance Services in Medicaid: A Review of Four State Programs [PDF]

open access: yes, 2008
Discusses eligibility for and use of Consumer Direction of Personal Assistance Services, which give beneficiaries control over the hiring, scheduling, training and paying of personal care attendants, in California, Colorado, New York, and ...
Henry Claypool, Molly O'Malley
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization

open access: yesNature Communications, 2017
C-H activation is a powerful method to form functionalised molecules, but is particularly challenging for unactivated sp3sites. Here the authors report a directing-group-free radical cascade process for converting vinyl azides and carboxylic acids to ...
Wei Shu   +3 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Home - About - Disclaimer - Privacy