Results 71 to 80 of about 2,491,696 (297)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

The plot of the directional derivative of the ProjPSO-generated design confirms it is D-optimal design for the IC Model A.

open access: yes, 2015
The plot of the directional derivative of the ProjPSO-generated design confirms it is D-optimal design for the IC Model A.
Chien-Chih Huang (757880)   +3 more
core   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

open access: yesFEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt   +2 more
wiley   +1 more source

Generalized Convexity via Clarke Subdifferential of Interval Mappings and Its Optimization Applications

open access: yesAxioms
Clarke subdifferential and directional derivative theories are well developed for real functions. However, the nonsmooth analysis framework for interval mappings is still incomplete.
Shexiang Hai, Yanmei Zhang
doaj   +1 more source

Some Minimax Type Results Of Clarke\u27s Generalized Directional Derivative And Point-Coderivative Of Multifunctions

open access: yes, 2002
In this paper, we will apply some results which are associated with the techniques of KKM mapping and Fan-KKM Theorem to prove a fixed point theorem and to reprove a theorem of variational inequalities (Theorem 2 [3]) which relates with Clarke s ...
Li, Jinlu, Isac, G, J. Li, G. Isac
core   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng   +4 more
wiley   +1 more source

Exponential Stabilizability of Switched Systems with Polytopic Uncertainties

open access: yesJournal of Applied Mathematics, 2012
The exponential stabilizability of switched nonlinear systems with polytopic uncertainties is explored by employing the methods of nonsmooth analysis and the minimum quadratic Lyapunov function.
Xia Zhang, Zun-Quan Xia, Yan Gao
doaj   +1 more source

Directional derivative of vector field and regular curves on time scales

open access: yes, 2006
The general idea in this paper is to study curves of the parametric equations where the parameter varies in a so-called time scale, which may be an arbitrary closed subset of the set of all real numbers.
Emin Özyilmaz, Ozyilmaz, Emin
core   +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle   +4 more
wiley   +1 more source

Synthesis of branch-guide directional couplers and filter prototypes [PDF]

open access: yes, 1968
The object of this thesis is the solution of the following problems using the theories of lumped and distributed network synthesis: (1) Synthesis of equally terminated, lumped and. distributed filters containing an even number of elements.
Lind, Larry Frederick
core   +4 more sources

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