Results 51 to 60 of about 2,997,836 (405)
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Advancing Opportunities: Accomodations Resources for Federal Managers and Employees [PDF]
, 2005 [Excerpt] Every day the nation benefits from the contributions of individuals with disabilities who serve in the federal workforce. Many of these individuals are entitled to workplace adjustments, or accommodations, in order to effectively carry out ...
Office of Disability Employment Policy
core +1 more source
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
History of Psychiatry, 2014 How does society imagine mental illness? Does this shift radically over time and with different social attitudes as well as scientific discoveries about the origins and meanings of mental illness? What happens when we begin to think about mental illness as madness, as a malleable concept constantly shifting its meaning?
openaire +3 more sources
Career-focused Mentoring for Youth: The What, Why, and How? [PDF]
, 2007 [Excerpt] When asked to describe an ideal employee, attributes such as being a hard worker, a team player, and a good communicator are frequently cited by employers as being even more important than technical expertise.
Office of Disability Employment Policy
core +1 more source
Care work: dreaming disability justice
Disability & Society, 2019 Care Work: Dreaming Disability Justice is a collection of visionary essays on vibrant organizing for Disability Justice that is gathering momentum across the unceded and occupied Indigenous territo...
Alise de Bie +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Workforce Intermediaries: Strategic Connections For Youth With Disabilities [PDF]
, 2005 [Excerpt] Over the last two decades, landmark legislation, successful initiatives and technological advances have helped improve employment opportunities for people with disabilities.
Office of Disability Employment Policy
core +1 more source
The Promise of Empathy: Design, Disability, and Knowing the "Other"
International Conference on Human Factors in Computing Systems, 2019 This paper examines the promise of empathy, the name commonly given to the initial phase of the human-centered design process in which designers seek to understand their intended users in order to inform technology development.
Cynthia L. Bennett, D. Rosner
semanticscholar +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source