Results 51 to 60 of about 2,492,272 (348)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Development, implementation, and scalability of the Family Engagement in Research Course: a novel online course for family partners and researchers in neurodevelopmental disability and child health

Research Involvement and Engagement
Background Since 2011 when the Canadian Institutes of Health Research launched the Strategy for Patient Oriented Research, there has been a growing expectation to embed patient-oriented research (POR) in the health research community in Canada.
Andrea Cross, Alice Kelen Soper, Donna Thomson, Connie Putterman, Dayle McCauley, Samantha K. Micsinszki, Rachel Martens, Patricia Solomon, Lorraine Carter, James N. Reynolds, Olaf Kraus de Camargo, Jan Willem Gorter   +11 more
doaj   +1 more source

Workforce Intermediaries: Strategic Connections For Youth With Disabilities [PDF]

, 2005
[Excerpt] Over the last two decades, landmark legislation, successful initiatives and technological advances have helped improve employment opportunities for people with disabilities.
Office of Disability Employment Policy
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Understanding the Impact of Assistive Technology on Users’ Lives in England: A Capability Approach

Bioengineering
This study presents an analysis of England’s 2023 national assessment of assistive technology (AT) access and use, with a particular focus on the qualitative impact of AT as described by users.
Rebecca Joskow, Dilisha Patel, Anna Landre, Kate Mattick, Catherine Holloway, Jamie Danemayer, Victoria Austin   +6 more
doaj   +1 more source

Encouraging Future Innovation: Youth Entrepreneurship Education [PDF]

, 2005
[Excerpt] Entrepreneurs drive America’s economy, accounting for the majority of our nation’s new job creation and innovations. According to the U. S. Census Bureau’s 2002 Survey of Business Owners, self-employed individuals who have no paid employees ...
Office of Disability Employment Policy
core   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Diverse Perspectives: People With Disabilities Fulfilling Your Business Goals [PDF]

, 2005
[Excerpt] By fostering a culture of diversity, or a capacity to appreciate and value individual differences, in all aspects of their operations, employers benefit from varied perspectives on how to confront business challenges and achieve success ...
Office of Disability Employment Policy
core   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

Opening Doors to all Candidates: Tips for Ensuring Access for Applicants with Disabilities [PDF]

, 2005
[Excerpt] The goal of the hiring process is to attract and identify the individual who has the best mix of skills and attributes for the job available. Ensuring that all qualified individuals can participate in the process is key to achieving this goal ...
Office of Disability Employment Policy
core   +1 more source