Results 51 to 60 of about 893,441 (290)

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Development, implementation, and scalability of the Family Engagement in Research Course: a novel online course for family partners and researchers in neurodevelopmental disability and child health

Research Involvement and Engagement
Background Since 2011 when the Canadian Institutes of Health Research launched the Strategy for Patient Oriented Research, there has been a growing expectation to embed patient-oriented research (POR) in the health research community in Canada.
Andrea Cross, Alice Kelen Soper, Donna Thomson, Connie Putterman, Dayle McCauley, Samantha K. Micsinszki, Rachel Martens, Patricia Solomon, Lorraine Carter, James N. Reynolds, Olaf Kraus de Camargo, Jan Willem Gorter   +11 more
doaj   +1 more source

Universal Design for Learning for Children with ADHD

Children, 2023
Attention Deficit–Hyperactivity Disorder (ADHD) is a psychiatric condition that shows developmentally inappropriate levels of inattention, hyperactivity, or impulsivity.
Alessandro Frolli, Francesco Cerciello, Clara Esposito, Maria Carla Ricci, Rossana Pia Laccone, Fabio Bisogni   +5 more
doaj   +1 more source

Methods for working with problem residents in medical physics residency education

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Medical physics residency training programs may occasionally encounter residents requiring additional intervention beyond normal training efforts. In the literature, these residents are referred to as “problem” residents. While the physician literature on the subject is valuable, this paper specifically focuses on dealing with a problem ...
Christopher J. Watchman, Dandan Zheng
wiley   +1 more source

Memory performance on the Auditory Inference Span Test is independent of background noise type for young adults with normal hearing at high speech intelligibility

Frontiers in Psychology, 2014
Listening in noise is often perceived to be effortful. This is partly because cognitive resources are engaged in separating the target signal from background noise, leaving fewer resources for storage and processing of the content of the message in ...
Niklas eRönnberg, Niklas eRönnberg, Mary eRudner, Mary eRudner, Thomas eLunner, Thomas eLunner, Thomas eLunner, Thomas eLunner, Stefan eStenfelt, Stefan eStenfelt   +9 more
doaj   +1 more source

Evaluation of dosimetric and spatial accuracy of a virtual cone technique for radiosurgery using linac‐integrated CBCT‐based polymer gel dosimetry

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study evaluates the dosimetric and geometric precision of a virtual cone technique using CBCT‐based polymer gel dosimetry, enabling radiation delivery, and imaging readout within an identical spatial coordinate system. Methods We created a C# script for a virtual cone technique that generates a treatment plan with 10 gantry arcs ...
Tenzin Kunkyab, Michael Lamey, Andrew Jirasek, Michael Kudla, Nathan Becker, Benjamin Mou, Derek Hyde   +6 more
wiley   +1 more source

Implementation of Automata Theory to Improve the Learning Disability [PDF]

Sindh Univ. Res. Jour. (Sci. Ser.) Vol. 45 (1):1193-196 (2013), 2013
There are various types of disability egress in world like blindness, deafness, and Physical disabilities. It is quite difficult to deal with people with disability. Learning disability (LD) is types of disability totally different from general disability. To deal children with learning disability is difficult for both parents and teacher.
arxiv  

Risk analysis of the Unity 1.5T MR‐Linac adapt‐to‐shape workflow

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background and Purpose The adapt‐to‐shape (ATS) workflow on the Unity MR‐Linac (Elekta AB, Stockholm, Sweden) allows for full replanning including recontouring and reoptimization5. Additional complexity to this workflow is added when the adaptation involves the use of MIM Maestro (MIM Software, Cleveland, OH) software in conjunction with ...
Jiayi Liang, Eric Aliotta, Neelam Tyagi, Paola Godoy Scripes, Nicolas Côté, Ergys Subashi, Qijie Huang, Lian Sun, Ching‐Yun Chan, Angela Ng, Theresa Wunner, Victoria Brennan, Kaveh Zakeri, James Mechalakos   +13 more
wiley   +1 more source