Results 281 to 290 of about 118,573 (345)

Regenerative strategies for intervertebral disc degeneration. [PDF]

J Orthop Translat
Ogaili RH, Alassal A, Za'aba NF, Zulkiflee I, Mohd Isa IL.   +4 more
europepmc   +1 more source

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Elemental imbalance and oxidative biomarker shifts in lumbar disc degeneration. [PDF]

Front Neurol
Strojny D, Wojdyła R, Skóra K, Hoczela M, Wyczarska-Dziki K, Rajchel M, Miller M, Sobański D, Staszkiewicz R, Wieczorek J, Chwalba A, Rogoziński P, Grabarek BO.   +12 more
europepmc   +1 more source

[Retracted] MicroRNA‑25‑3p regulates human nucleus pulposus cell proliferation and apoptosis in intervertebral disc degeneration by targeting Bim. [PDF]

Mol Med Rep
Zhao Z, Zheng J, Ye Y, Zhao K, Wang R, Wang R.   +5 more
europepmc   +1 more source

SOD1 lactylation impair its enzymatic activity by conformational change to aggravate intervertebral disc degeneration. [PDF]

Nat Commun
Zhang Y, Zhai Y, Liu C, Chen M, Zhang Y, Bian Z, Chang X, Hu Z, Li J, Zhang C, Ni Z, Xie Y, Chen L, Liu M, Li C.   +14 more
europepmc   +1 more source

Innovating intervertebral disc degeneration therapy: Harnessing the power of extracellular vesicles

Shanfeng Chen, Yiming Dou, Yiming Zhang, Xun Sun, Xinyu Liu, Qiang Yang   +5 more
openalex   +1 more source

TRIM21 accelerates ferroptosis in intervertebral disc degeneration by promoting SLC7A11 ubiquitination and degradation. [PDF]

Open Life Sci
Yu W, Liu Y, Zhou F.
europepmc   +1 more source

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism. [PDF]

Adv Sci (Weinh)
Joyce K, Scheper AF, Phyo AM, Flaherty RO, Drake R, Devitt A, Marchetti-Deschmann M, Saldova R, Pandit A.   +8 more
europepmc   +1 more source

Zmpste24 deficiency contributes to intervertebral disc degeneration by undermining the stability of the nuclear membrane of nucleus pulposus cells

Han Chen, SN Fu, Hao Wang, Kai Zhang, Jie Zhao   +4 more
openalex   +1 more source

FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3. [PDF]

Aging Cell
Wu ZL, Ran R, Xie QQ, Zhang C, Chen YJ, Cheng P, Wang KP, Zhang HH.   +7 more
europepmc   +1 more source