Results 51 to 60 of about 223,276 (323)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Fishery discards: factors affecting their variability within a demersal trawl fishery. [PDF]
PLoS ONE, 2012 Discards represent one of the most important issues within current commercial fishing. It occurs for a range of reasons and is influenced by an even more complex array of factors.
Jordan Feekings +3 more
doaj +1 more source
Overlooked impacts and challenges of the new European discard ban [PDF]
, 2015 Discards are the portion of animal and plant material in the catch that is dumped back at sea. The Common Fisheries Policy plan proposed by the European Commission for 2014-2020 presents a controversial goal: to enforce the landing of fishing discards as
Coll, Marta +3 more
core
Development of bioprocesses for the integral valorisation of fish discards
Biochemical engineering journal, 2019 In the present work, we have developed a set of sequential and complementary alternatives to valorise five fish discards in order to recover and produce fish mince, oils, gelatins, fish protein hydrolysates (FPHs) with antioxidant and antihypertensive ...
J. Vázquez +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Scientia Marina, 2009 For several decades, the black scabbardfish (Aphanopus carbo, Lowe 1839) has been a valuable resource for fishing communities in Madeira and more recently for those in mainland Portugal.
Pedro Bordalo-Machado +6 more
doaj +1 more source
Description of resonances within the rigged Hilbert space [PDF]
, 2006 The spectrum of a quantum system has in general bound, scattering and resonant parts. The Hilbert space includes only the bound and scattering spectra, and discards the resonances.
de la Madrid, R.
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Reconstructed Russian Fisheries Catches in the Barents Sea: 1950-2014
Frontiers in Marine Science, 2018 The management of marine living resources that straddle country borders has historically been a challenge, particularly in cases where political tensions are high.
Sarah Popov, Dirk Zeller
doaj +1 more source