Results 41 to 50 of about 2,491,691 (285)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Patients’ Perceptions of Relative Importance of Discharge Elements (PRIDE) Study [PDF]
, 2019 Background: Almost 20% of patients experience potentially preventable adverse events within 30 days of hospital discharge (Forster, et al, 2003). The Agency for Healthcare Research and Quality recommends structured and patient-centered discharge ...
Kurbanova, Nargiza
core +1 more source
Contextual analysis of health care at discharge in leprosy: an integrative review [PDF]
, 2019 Objective: To analyze contextual relations of health care in the discharge of leprosy. Method: An analytical, reflexive study based on the theoretical framework of context analysis, elaborated through an integrative review of literature in the databases ...
Gomes, Bruna RS +5 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
DATA CLASSIFICATION TECHNIQUES AND SYSTEM FOR PREDICTING DISCHARGES IN THE GAMBIA RIVER BASIN [PDF]
Analele Universităţii din Oradea: Seria Geografie, 2019 Within the framework of water resources management, numerous research works and methods were led in world. In this trail, we noted a fast development of time series data mining (TSDM) which supplies a new method for water resources management.
Cheikh FAYE +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić +3 more
wiley +1 more source
A Model for Hospital Discharge Preparation: From Case Management to Care Transition [PDF]
, 2015 There has been a proliferation of initiatives to improve discharge processes and outcomes for the transition from hospital to home and community-based care.
Bahr, Sarah J. +5 more
core +1 more source
Development of a novel clinical scoring system for on-farm diagnosis of bovine respiratory disease in pre-weaned dairy calves. [PDF]
, 2014 Several clinical scoring systems for diagnosis of bovine respiratory disease (BRD) in calves have been proposed. However, such systems were based on subjective judgment, rather than statistical methods, to weight scores.
Aly, Sharif S +4 more
core +2 more sources
BMC Health Services ResearchBackground While successful information transfer and seamless medication supply are fundamental to medication safety during hospital-to-home transitions, disruptions are frequently reported.
Sophia Klasing +5 more
doaj +1 more source