Results 41 to 50 of about 8,035,233 (306)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Partial discharge behavior and insulation failures detection in electrical devices subjected to impulse voltage excitation

International Journal of Electrical Power & Energy Systems
Partial discharges can occur within an insulating system due to flaws in the material and can cause continuous deterioration until a full breakdown occurs.
Manuel Eckert, Petr Mraz, Christof Ballweg, Josef Pihera   +3 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Uncertainty regarding instantaneous discharge obtained from stage–discharge rating curves built with low density discharge measurements

Ingeniería e Investigación, 2012
This work concerned uncertainty analysis for constructing stage–discharge rating curves to estimate error or uncertainty regarding calculated discharges, considering different discharge measurement availability scenarios.
Juan Felipe Martínez Plata, Efraín Antonio Domínguez Calle, Hebert Gonzalo Rivera   +2 more
doaj  

Swath-altimetry measurements of the main stem Amazon River: measurement errors and hydraulic implications [PDF]

Hydrology and Earth System Sciences, 2015
The Surface Water and Ocean Topography (SWOT) mission, scheduled for launch in 2020, will provide a step-change improvement in the measurement of terrestrial surface-water storage and dynamics.
M. D. Wilson, M. Durand, H. C. Jung, D. Alsdorf   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Effect of length of the observed dataset on the calibration of a distributed hydrological model [PDF]

Proceedings of the International Association of Hydrological Sciences, 2015
Calibration of hydrological models in ungauged basins is now a hot research topic in the field of hydrology. In addition to the traditional method of parameter regionalization, using discontinuous flow observations to calibrate hydrological models has ...
X. Cui, W. Sun, J. Teng, H. Song, X. Yao
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Modeling the Effects of the Cathode Composition of a Lithium Iron Phosphate Battery on the Discharge Behavior

Energies, 2013
This paper reports a modeling methodology to predict the effects on the discharge behavior of the cathode composition of a lithium iron phosphate (LFP) battery cell comprising a LFP cathode, a lithium metal anode, and an organic electrolyte.
Won Il Cho, Seung Ho Yu, Chee Burm Shin, Jaeshin Yi, Jeongbin Lee   +4 more
doaj   +1 more source

Width‐Based Discharge Partitioning in Distributary Networks: How Right We Are

Geophysical Research Letters, 2022
River deltas are home to large populations and can be composed of complex channel networks which convey flows of matter to the shoreline. Knowledge of flow within individual channels is needed to quantify the distribution of discharge across the delta ...
Jayaram Hariharan, Anastasia Piliouras, Jon Schwenk, Paola Passalacqua   +3 more
doaj   +1 more source