Results 91 to 100 of about 108,296 (296)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Jesus: His Life from the Perspectives of Mary Magdalene and the Apostle Peter (Pt.4)

open access: yes, 2019
The final two episodes of the History Channel’s “Jesus: His Life” focus on Jesus as viewed by Mary Magdalene and the Apostle Peter. As with the previous six episodes, this hybrid documentary focuses on the life of Jesus from the perspectives of ...
Anderson, Paul N.
core  

The religion of the ISKCON Vaishnavas in the perspectives of diacritical theology [PDF]

open access: yes, 1997
In Germany, theological studies on the Hindu religion of the International Soci-ety of Krishna Consciousness and its Vaishnava theology are still only just be-ginning. Previously this relevant task was left mostly to religio-political polemics, resulting
Weber, Edmund
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Public Witness through the Church as the Disciple Community in the Context of Christian Nationalism

open access: yesБогословські роздуми: Східноєвропейський журнал богословʼя
In Central and Eastern Europe, some branches of the Church have formed alliances with nationalist politics characterized by fundamentalism and fanaticism.
Myra Watkins
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Volume 53, Number 3 - May 1974 [PDF]

open access: yes, 1974
Volume 53, Number 3 - May 1974. 23 pages including covers and advertisements. Contributions Selley, April The Skyscraper Mancusi, Michael Stanford Station Fuoroli, Caryn Please . . .

core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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